Bioorganic and Medicinal Chemistry Letters p. 3455 - 3458 (2014)
Update date:2022-08-04
Topics:
Hoekstra, William J.
Garvey, Edward P.
Moore, William R.
Rafferty, Stephen W.
Yates, Christopher M.
Schotzinger, Robert J.
While the orally-active azoles such as voriconazole and itraconazole are effective antifungal agents, they potently inhibit a broad range of off-target human cytochrome P450 enzymes (CYPs) leading to various safety issues (e.g., drug-drug interactions, li
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