Synthesis of a ring a precursor of doxorubicin: Stereoselective control of the epoxidation of a homoallylic alcohol by hydroxyl and ester groups

Article abstract of DOI:10.1016/S0040-4039(00)74309-7

The key step in a synthesis of a precursor for ring A in doxorubicin is the stereoselective control of the epoxidation of a homoallylic alcohol by ester and hydroxyl groups; the result leads to a new method of forming lactones in excellent yields under ne