N. Salehi, B. B. F. Mirjalili
Table 3 Catalytic performances of nano-ovalbumin versus other catalysts for synthesis of 5a
Entry
Catalyst
Conditions
Time (min)/yielda (%) [Ref.]
1
2
3
4
5
6
Nano-CuCr2O4 (4 mol%)
EtOH/25 °C
H2O/r.t.
50/90 [25]
Fe3O4/KCC1/IL/HPWMNPs (0.0001 mg)
Nano-CdZr4(PO4)6 (0.6 mol%)
FeNi3-ILs MNPs (0.002 g)
30/96 [27]
EtOH/reflux
EtOH/reflux
EtOH/MW
H2O/55 °C
43/88 [26]
48/86 [28]
Nano-Fe3O4@SiO2-SO3H (0.004 g)
Nano-ovalbumin (0.05 g)
20/90 [29]
45/93 [this work]
aIsolated yields
nano-ovalbumin from egg white by a simple method, (2) the metal-free nature of
biocatalyst, (3) reusability of the biocatalyst, (4) use of water as a green solvent, (5)
mild reaction conditions and less pollution and (6) excellent yields and purities of
products. Moreover, this is the first report of synthesizing biologically interesting
tetrahydrodipyrazolo pyridines using a biocatalyst that could be a valuable synthetic
alternative for such four-component reactions in biotechnological processes.
Acknowledgements The Research Council of Yazd University is gratefully acknowledged for the
financial support for this work.
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