Synthesis of 1,2,3,4-tetrahydro-4-oxothieno[3,2-d]pyrimidine and perhydropyrimidine derivates from alkyl dicyanoacetates

Article abstract of DOI:10.1002/hlca.19910740315

Nucleophilic addition of methyl 3-aminothiophene-2-carboxylate (2) as well as of β-alanine ethyl ester (11) to one CN group of the salts 1 of alkyl dicyanoacetates, followed by cyclization, yielded 1,2,3,4-tetrahydro-4-oxo- thieno[3,2-d]pyridimine derivat