Chemical and Pharmaceutical Bulletin p. 1846 - 1848 (1991)
Update date:2022-08-04
Topics:
Eguchi
Ishikawa
Several 5-substituted derivatives of 7-ethoxycarbonyl-6,8-dimethyl-1(2H)-phthalazinone were prepared by means of nitration, reductive amination, and diazonium decomposition. The substituents introduced include NO2, NH2, F, Cl, CN. Among the derivatives, the fluorine compound was obtained only in poor yield because intramolecular cyclization occurred predominantly.
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Doi:10.1021/ol301647g
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