Reaction of Sodium Dithionite Activated Mitomycin C with Guanine at Non-Cross-Linkable Sequences of Oligonucleotides

DOI: 10.1021/jo00016a005

Source and publish data:

Journal of Organic Chemistry p. 4826 - 4829 (1991)

Update date:2022-08-04

Topics:

Authors:

McGuinness, Brian F.

Lipman, Roselyn

Nakanishi, Koji

Tomasz, Maria

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Article abstract of DOI:10.1021/jo00016a005

The reaction of sodium dithionite activated mitomycin C with guanine at non-cross-linkable sequences in oligonucleotides (as well as DNA) yielded a mixed 1''-deoxyguanosine,10''-sulfonate mitosene derivative, which has implications for published model activation and DNA alkylation studies of this antitumor antibiotic as well as its in vivo mode of action.

Full text of DOI:10.1021/jo00016a005

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