Journal of Organic Chemistry p. 4826 - 4829 (1991)
Update date:2022-08-04
Topics:
McGuinness, Brian F.
Lipman, Roselyn
Nakanishi, Koji
Tomasz, Maria
The reaction of sodium dithionite activated mitomycin C with guanine at non-cross-linkable sequences in oligonucleotides (as well as DNA) yielded a mixed 1''-deoxyguanosine,10''-sulfonate mitosene derivative, which has implications for published model activation and DNA alkylation studies of this antitumor antibiotic as well as its in vivo mode of action.
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