Reaction of Sodium Dithionite Activated Mitomycin C with Guanine at Non-Cross-Linkable Sequences of Oligonucleotides

Article abstract of DOI:10.1021/jo00016a005

The reaction of sodium dithionite activated mitomycin C with guanine at non-cross-linkable sequences in oligonucleotides (as well as DNA) yielded a mixed 1''-deoxyguanosine,10''-sulfonate mitosene derivative, which has implications for published model activation and DNA alkylation studies of this antitumor antibiotic as well as its in vivo mode of action.