Chemistry of Heterocyclic Compounds p. 225 - 227 (1991)
Update date:2022-09-26
Topics:
Ivanov, E. I.
Yavolovskii, A. A.
Kuklenko, E. A.
Timofeev, O. S.
Depending on the base used, reaction of 3-(β-hydroxyethyl)-8-thiaxanthine with p-toluenesulfonylchloride either stops at the stage of formation of the tosylate or gives 1,2,5-thiadiazolo<3,4-d>oxazolidino<2,3-b>pyrimidin-9(4H)-one.Upon treatment with ammonia or methylamine, both of these compounds react to give 3-(β-hydroxyethyl)-8-thiaguanines.
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