Stabilization of DNA duplex by 2-substituted adenine as a minor groove modifier

Article abstract of DOI:10.1016/j.bmcl.2011.09.104

2-(1-Naphthalenylethynyl)-2′-deoxyadenosine (^NA) was synthesized and incorporated into oligodeoxynucleotides. DNA duplexes containing newly designed 5′-^NAT-3′/3′-T^NA- 5′ base pairs are considerably stabilized than unmodifi