CO/C-H as an acylating reagent: A palladium-catalyzed aerobic oxidative carbonylative esterification of alcohols

Article abstract of DOI:10.1002/anie.201400612

A palladium-catalyzed oxidative carbonylative esterification of a variety of functionalized alcohols under base- and ligand-free conditions has been demonstrated. A CO/olefin combination was utilized as the acylating reagent with O₂ as a benign oxidant. Notably, the scope of the substrate alcohols has been greatly broadened. New choice: A palladium-catalyzed oxidative carbonylative esterification of a variety of functionalized alcohols under base- and ligand-free conditions is demonstrated, and a CO/olefin combination is utilized as the acylating reagent with O₂ as a benign oxidant. Notably, scope of the substrate alcohols has been greatly broadened.