OCTATHYMIDYLATES INVOLVING ALTERNATING NEOPENTYLPHOSPHOTHIONOTRIESTER-PHOSPHODIESTER LINKAGES WITH CONTROLLED STEREOCHEMISTRY AT THE MODIFIED P-CENTER

DOI: 10.1016/S0040-4039(00)74364-4

Source and publish data:

Tetrahedron Letters p. 2497 - 2498 (1991)

Update date:2022-08-03

Topics:

Authors:

Hau, J. F.

Asseline, U.

Thuong, N. T.

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Article abstract of DOI:10.1016/S0040-4039(00)74364-4

Starting from each pure stereoisomer of neopentylphosphothionotriester dimer, octathymidylates involving alternating stereoregular neopentylphosphothionotriester-phosphodiester linkages and covalently linked to an acridine derivative at their 3'-end have been synthesized.Their stability towards nuclease degradation was studied by comparison with an octanucleotide-acridine conjugate containing only phosphodiester groups.

Full text of DOI:10.1016/S0040-4039(00)74364-4

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