Synthetic Communications p. 672 - 676 (2018)
Update date:2022-08-04
Topics: NMR spectroscopy Enantiomeric excess (ee) Reaction Conditions Asymmetric Hydrogenation Catalyst Loading Iridium-Catalyzed β-keto esters f-amphox ligands
Qin, Chao
Chen, Xiu-Shuai
Hou, Chuan-Jin
Liu, Hongzhu
Liu, Yan-Jun
Huang, De-Zhi
Hu, Xiang-Ping
The iridium-catalyzed asymmetric hydrogenation of β-keto esters with chiral tridentate P,N,N-ligands (f-amphox) has been developed. Under the optimized conditions, a wide range of β-keto esters can be hydrogenated smoothly, affording the corresponding β-hydroxy esters in good to excellent enantioselectivities (up to 95% ee).
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