An efficient protocol for the synthesis of monofluoroalkylated (hetero)arenes via Pd-catalyzed α-(hetero)arylation of α-fluoroketones with (hetero)aryl bromides

Article abstract of DOI:10.1016/j.tetlet.2020.151948

An efficient synthesis of monofluoroalkylated N-heteroarenes using α-fluoroketones as monofluoroalkyl reagents was developed. A variety of novel α-(hetero)aryl-α-fluoroketones and monofluoroalkylated N-heteroarenes were obtained in moderate to good yields. Notable advantages of this protocol include a low catalyst loading, easily prepared monofluoroalkyl reagents and wide substrate scope.