Journal of Medicinal Chemistry p. 3182 - 3187 (1991)
Update date:2022-07-29
Topics:
Bergeron
Wiegand
McManis
Perumal
A new and versatile route to desferrioxamine B (DFO, 1) is described. Hydroxamate reagent 4 was elaborated in a series of high yield steps to the tert-butoxycarbonyl nitrile 11, which provided DFO in three transformations. The intermediate 11 could also be utilized in the preparation of DFO analogues which contain terminal N-acyl groups other than acetyl. The methodology was further employed in the syntheses of the DFO polyether analogues 2 and 3, beginning with the 3,6,9-trioxadecylation of N-(tert- butoxycarbonyl)-O-benzylhydroxylamine. Polyethers 2 and 3 are neutral molecules, which are somewhat more lipophilic than the parent DFO. Polyether hydroxamate 2 was shown to be nearly 3 times as effective as desferrioxamine at clearing iron in rats.
View MoreSuzhou Lixin Pharmaceutical Co., Ltd.
Contact:86-512-88169812
Address:21 Tangxi Road, Suzhou New District, Suzhou 215151
Zouping Mingxing Chemical Co.,Ltd.
website:http://www.zoutong.com.cn
Contact:86-543-2240068 2240067
Address:428 Daixi Third Road Zouping County Shandong Province China
Hengshui Bangsheng Environmental Protection and Technology Co., Ltd
Contact:+86-318-2275966
Address:1956 Renmin Road, Hengshui city, Hebei, China
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
NingBO Hong Xiang Biochem.Co.Ltd
website:http://www.hxbiochem.com
Contact:0574-66003444
Address:Ning Bo Bei Lun
Doi:10.1021/ol203413w
(2012)Doi:10.1021/cg201652h
(2012)Doi:10.1016/j.crci.2015.10.014
(2016)Doi:10.1016/j.bmc.2011.10.053
(2012)Doi:10.1002/adsc.201300077
(2013)Doi:10.1002/jhet.796
(2012)