A novel application of a [3+2] cycloaddition reaction for the synthesis of the piperazinone rings of pseudotheonamides A1 and A2

Article abstract of DOI:10.1016/S0040-4039(02)00133-8

A novel approach to synthesize the piperazinone ring system of pseudotheonamide A₁ and A₂ is described. The key step is the intramolecular [3+2] cycloaddition reaction of a suitably orientated azide and an α,β-unsaturated ester.