Solid Phase Synthesis of 5',3'-Bifunctional Oligodeoxyribonucleotides Bearing a Masked Thiol Group at the 3'-End

Article abstract of DOI:10.1016/0040-4039(91)80686-Z

Immobilization of the "disulfide arm" 8 on a solid support via a succinyl linkage allows the automated synthesis of modified oligonucleotides bearing a disulfide or a thiol function at the 3'-end and other modifications at the 5'-end.