Synthesis of optically active α,α-distubstituted β-keto esters via chiral β-enamino esters

Article abstract of DOI:10.1016/S0957-4166(00)82164-3

Michael addition of chiral β-enamino esters to MVK and acrylates promoted by Lewis acids (ZnCl₂, MgBr₂) or high pressure (11-14 Kbar) afforded, after hydrolytic work-up, α,α-disubstituted β-keto esters in good enantiomeric carbon exc