Synthesis and evaluation of cytotoxic effects of novel α- methylenelactone tetracyclic diterpenoids

DOI: 10.1016/j.bmcl.2012.01.051

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1922 - 1925 (2012)

Update date:2022-08-04

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Authors:

Zeng, Yao-Fu

Wu, Jia-Qiang

Shi, Lian-Yong

Wang, Ke

Zhou, Bin

Tang, Yong

Zhang, Da-Yong

Wu, Yang-Chang

Hua, Wei-Yi

Wu, Xiao-Ming

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Article abstract of DOI:10.1016/j.bmcl.2012.01.051

A series of tetracyclic diterpenoids bearing the α-methylenelactone group have been synthesized and screened for their in vitro anti-tumor activities against six human cancer cell lines. The results showed that compounds 1c, 2a and 2b exhibited significan

Full text of DOI:10.1016/j.bmcl.2012.01.051

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