A synthesis of 5'-O-acryloyl-5-fluorouridine by use of p-methoxybenzyl group as an N3-imide protecting group of 5-fluorouridine

Article abstract of DOI:10.1246/bcsj.64.2266

5'-O-Acryloyl-5-fluorouridine was preparedd by use of p-methoxybenzyl (PMB) group as an N³-imide protecting group of 5-fluorouridine. PMB group was introduced chemoselectively by use of N,N-diisopropylethylamine or DBU as a base. A new deprotection method was developed by means of AlCl₃-anisole system at room temperature.