Enantiocontrolled Total Syntheses of (-)-Physovenine and (-)-Physostigmine

Article abstract of DOI:10.1021/jo00021a006

Enantiocontrolled total syntheses of the Calabar bean alkaloid (-)-physovenine (1) and (-)-physostigmine (2) have been achieved in a concise manner starting from the optically active tricyclic enone 3 employing a Fischer indolization reaction under nonacidic conditions as the key step.