A New Synthesis of Oxime Derivatives from Carbonyl Compounds and N,O-Bis(trimethylsilyl)hydroxylamine

Article abstract of DOI:10.1055/s-1987-28092

Reaction of a series of aldehydes and ketones with the potassium salt of N,O-bis(trimethylsilyl)hydroxylamine (2) gave high yields of the corresponding oximate anion 5.This anion, formed in a Peterson-type reaction, could be protonated to the oxime 7 or trapped in situ with a variety of electrophiles to give O-substituted oxime derivatives.