Journal of Medicinal Chemistry p. 3280 - 3284 (1991)
Update date:2022-08-05
Topics:
Driscoll, John S.
Marquez, Victor E.
Plowman, Jacqueline
Liu, Paul S.
Kelley, James A.
Barchi, Joseph J.
2(1H)-Pyrimidinone riboside (zebularine, 1b) and its 5-fluoro (6b) and 2'-ara-fluoro (7b) analogues have been synthesized and evaluated in vivo as antitumor agents.Zebularine provides increase in life span (ILS) values of ca. 70percent against intraperito
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