A FORMAL SYNTHESIS OF ASPARTAME VIA THE OXAZIRIDINE - AMIDE REARRANGEMENT

DOI: 10.1016/S0040-4039(00)96156-2

Source and publish data:

Tetrahedron Letters p. 2595 - 2596 (1987)

Update date:2022-07-30

Topics:

Authors:

Duhamel, Pierre

Goument, Bertrand

Plaquevent, Jean - Christophe

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)96156-2

A formal synthesis of the dipeptide sweetener aspartame via the oxaziridine - amide rearrangement is reported.Thus, the peptidic oxaziridine 4 was prepared and was photochemically isomerized into the aspartame precursor 5.

Full text of DOI:10.1016/S0040-4039(00)96156-2

Products guided by the article

Product name:(S)-2-{3-[(S)-1-(tert-Butyl-dimethyl-silanyl)-4-oxo-azetidin-2-yl]-oxaziridin-2-yl}-3-phenyl-propionic acid methyl ester

Cas No:136781-40-3

R&D Labs maybe for 136781-40-3

jiangsu hualin chemical co.,ltd.

Contact:86-25-87787402

Address:jaingsu,china
Tianjin Boron PharmaTech Co.,Ltd.(expird)

Contact:86-022-59845187

Address:B9-401, Tianda Science Park,No.80,4th Avenue,TEDA,Tianjin, China
YORK CHEMICALS LTD

Contact:+1 (647) 918 5848

Address:2343 BRIMLEY RD., Suite 250
zhuzhou zhongle chemical co. ltd.

Contact:+86-0731 28228409

Address:Zhuzhou, Hunan, China
Chengdu Yunyi International Trade Co., Ltd

Contact:

Address:china

Relevant to this article

Palladium-catalyzed asymmetric allylic alkylation using dimethyl malonate and its derivatives as nucleophile

Doi:10.1016/S0957-4166(00)86120-0
(1991)
Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress

Doi:10.1002/cmdc.201100522
(2012)
A tandem synthesis of polypropionate chains. Highly stereo< selective construction of the C(13)-C(25) segment containing nine contiguous chiral centers of swinholides A-C based on the stereospecific methylation of y, 5-epoxy acrylates by trimethylaluminiu

Doi:10.1039/a908342a
(1999)
PALLADIUM(0)-CATALYZED INTRA-AND INTERMOLECULAR CYCLIZATION REACTIONS OF ALLENE EPISULFIDES

Doi:10.1016/0040-4039(91)80042-5
(1991)
Synthesis of enantiomerically pure pyrrolidines by stereospecific cycloaddition of azomethine ylides with enones

Doi:10.1016/S0040-4039(00)73839-1
(1993)
Using DMF as Both a Catalyst and Cosolvent for the Regioselective Silylation of Polyols and Diols

Doi:10.1002/ejoc.201901195
(2019)

Article Doi