A FORMAL SYNTHESIS OF ASPARTAME VIA THE OXAZIRIDINE - AMIDE REARRANGEMENT

DOI: 10.1016/S0040-4039(00)96156-2

Source and publish data:

Tetrahedron Letters p. 2595 - 2596 (1987)

Update date:2022-07-30

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Authors:

Duhamel, Pierre

Goument, Bertrand

Plaquevent, Jean - Christophe

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Article abstract of DOI:10.1016/S0040-4039(00)96156-2

A formal synthesis of the dipeptide sweetener aspartame via the oxaziridine - amide rearrangement is reported.Thus, the peptidic oxaziridine 4 was prepared and was photochemically isomerized into the aspartame precursor 5.

Full text of DOI:10.1016/S0040-4039(00)96156-2

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