Synthesis of enantiomerically pure pyrrolidines by stereospecific cycloaddition of azomethine ylides with enones

Article abstract of DOI:10.1016/S0040-4039(00)73839-1

Several (E)-α,β-unsaturated ketones (enones) 2 bearing a chiral alkoxy or amino substituent in γ-position react with azomethine ylides 3 (obtained from glycine imines) in the presence of DBU/ AgOAc giving enantiomerically pure pyrrolidine derivatives 4 in