ACS Medicinal Chemistry Letters p. 607 - 611 (2015)
Update date:2022-08-04
Topics:
Khanfar, Mohammad A.
Quinti, Luisa
Wang, Hua
Nobles, Johnathan
Kazantsev, Aleksey G.
Silverman, Richard B.
Inhibitors of sirtuin-2 (SIRT2) deacetylase have been shown to be protective in various models of Huntington's disease (HD) by decreasing polyglutamine aggregation, a hallmark of HD pathology. The present study was directed at optimizing the potency of SI
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