Asymmetric synthesis of enantiomerically pure (-)-(1'R,4'R)-dioxolane-thymine and its anti-HIV activity

DOI: 10.1016/S0040-4039(00)79377-4

Source and publish data:

Tetrahedron Letters p. 3791 - 3794 (1991)

Update date:2022-08-03

Topics:

Authors:

Chu Chu

Ahn Ahn

Kim Kim

Beach Beach

Alves Alves

Jeong Jeong

Islam Islam

Van Roey

Schinazi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)79377-4

An asymmetric synthesis leading to the enantiomerically pure dioxolane-T has been achieved and its crystal structure has been determined and compared to the previously reported racemate. (-)-(1'R,4'R)-dioxolane-T was found to have potent and selective ant

Full text of DOI:10.1016/S0040-4039(00)79377-4

Products guided by the article

Product name:(-)-(2R,4R,1'S)-4-(2-O-benzoyl-1-hydroxyethyl)-2-<<(tert-butyldiphenylsilyl)oxy>methyl>dioxolane

Cas No:136884-12-3

R&D Labs maybe for 136884-12-3

Shanghai Rainbow Chemistry Co., Ltd.

Contact:+86-21-64968086-5815/5812

Address:3rd floor, Building 7, 251 Faladi Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai, P.R. China
Lian Xing Chemical Co.,Ltd.

Contact:0792-8228321

Address:10TH Floor No.121 binjiang Road Xunyang District
Langchem

Contact:+86+21-58956006 15800617331

Address:402 Room, 150# Cailun Road, Zhangjiang high tech park, Shanghai
Zhengzhou Xinlian Chemical Tech Co. ,Ltd

Contact:0371-65771781 021-52042910

Address:H Part, Building I, No. 700 Gonglu Road, Pudong New Area, Shanghai
Shandong Yaroma Perfumery Co., Ltd.

Contact:+86- 531- 88024598

Address:7-702 Caizhi Central, 59 Gong Ye South Road, Jinan City,250101, P. R. China

Relevant to this article

Development of coumarine derivatives as potent anti-filovirus entry inhibitors targeting viral glycoprotein

Doi:10.1016/j.ejmech.2020.112595
(2020)
Cycloaddition of nitrile oxides to 3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-α-D-ribo-hex-5-enofuranose

Doi:10.1016/0008-6215(92)84181-Q
(1991)
Dispersion energy enforced dimerization of a cyclic disilylated plumbylene

Doi:10.1021/ja300654t
(2012)
Studies on the Mechanism of Deacetoxy-Deacetylcephalosporin C Synthase using Cyclopropyl Substituted Cephalosporin Probes

Doi:10.1039/c39910000768
(1991)
Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors

Doi:10.1016/j.bmc.2013.11.045
(2014)
NEW OPTICALLY RESOLVED PERFLUORO(2-DIALKYLAMINO-PROPIONIC ACIDS)

Doi:10.1016/S0022-1139(00)80130-X
(1991)

Article Doi