Asymmetric synthesis of enantiomerically pure (-)-(1'R,4'R)-dioxolane-thymine and its anti-HIV activity

DOI: 10.1016/S0040-4039(00)79377-4

Source and publish data:

Tetrahedron Letters p. 3791 - 3794 (1991)

Update date:2022-08-03

Topics:

Authors:

Chu Chu

Ahn Ahn

Kim Kim

Beach Beach

Alves Alves

Jeong Jeong

Islam Islam

Van Roey

Schinazi

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Article abstract of DOI:10.1016/S0040-4039(00)79377-4

An asymmetric synthesis leading to the enantiomerically pure dioxolane-T has been achieved and its crystal structure has been determined and compared to the previously reported racemate. (-)-(1'R,4'R)-dioxolane-T was found to have potent and selective ant

Full text of DOI:10.1016/S0040-4039(00)79377-4

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