Time-dependent inhibition of Streptococcus faecalis D-alanine: D-alanine ligase by α-aminophosphonamidic acids

DOI: 10.1016/0223-5234(91)90057-T

Source and publish data:

European Journal of Medicinal Chemistry p. 255 - 260 (1991)

Update date:2022-07-30

Topics:

Authors:

Lacoste, AM

Chollet-Gravey, AM

Quang, L Vo

Quang, Y Vo

Goffic, F Le

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Article abstract of DOI:10.1016/0223-5234(91)90057-T

Some α-aminophosphonamidates which may mimic the transition state of D-alanine: D-alanine ligase catalytic reaction have been synthesized.The inhibition of the ligase by these compounds was investigated with Streptococcus faecalis enzyme using <14C>-D-Ala

Full text of DOI:10.1016/0223-5234(91)90057-T

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