Rational design and synthesis of novel Syk-kinase inhibitors

DOI: 10.1016/j.mencom.2012.03.006

Source and publish data:

Mendeleev Communications p. 73 - 74 (2012)

Update date:2022-08-04

Topics:

Authors:

Zeifman, Alexey A.

Titov, Ilya Yu.

Svitanko, Igor V.

Rakitina, Tatiana V.

Lipkin, Aleksey V.

Stroylov, Viktor S.

Stroganov, Oleg V.

Novikov, Fedor N.

Chilov, Ghermes G.

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Article abstract of DOI:10.1016/j.mencom.2012.03.006

Molecular modeling and subsequent synthesis of novel Syk-kinase inhibitors, 7H-pyrrolo[2,3-d]pyrimidine and 1,3,5-triazine derivatives, have been carried out. The best of the obtained compounds demonstrated to inhibit Syk-kinase activity at IC_{50
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Full text of DOI:10.1016/j.mencom.2012.03.006

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Product name:2,2-dimethyl-6-((4-((3,4,5-trimethoxyphenyl)amino)-1,3,5-triazine-2-yl)amino)-2H-pyrido[3,2-b][1,4]oxazine-3(4H)-one

Cas No:1373771-90-4

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