Dioxane dibromide mediated bromination of substituted coumarins under solvent-free conditions

Article abstract of DOI:10.3762/bjoc.8.35

An efficient solvent-free protocol for regioselective bromination of substituted coumarins has been developed by using dioxane dibromide as the solid brominating agent. The efficacy of the solvent-free protocol has been established. The effects of the electronic nature and location of the substituents on the outcome of the reaction have been rationalized with a proposed mechanism.