SYNTHESIS OF 18-SUBSTITUTED ANDROST-4-EN-3-ONE DERIVATIVES AS POTENTIAL INHIBITORS OF ALDOSTERONE BIOSYNTHESIS

DOI: 10.1016/S0040-4020(01)89733-7

Source and publish data:

Tetrahedron p. 7309 - 7322 (1991)

Update date:2022-08-06

Topics:

Authors:

Viger, Antoinette

Coustal, Suzy

Schambel, Philippe

Marquet, Andree

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Article abstract of DOI:10.1016/S0040-4020(01)89733-7

Androst-4-en-3-one derivatives substituted at the 18-methyl group bearing a 17-keto or 17-spirolactone function have been synthesized and tested in vitro as inhibitors of aldosterone biosynthesis

Full text of DOI:10.1016/S0040-4020(01)89733-7

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