An Improved Procedure for the Preparation of Substituted 4-Hydroxy-4,5-dihydrofurans

DOI: 10.1016/S0040-4039(00)92282-2

Source and publish data:

Tetrahedron Letters p. 4687 - 4690 (1991)

Update date:2022-07-30

Topics:

Authors:

Jauch, Johann

Schurig, Volker

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Article abstract of DOI:10.1016/S0040-4039(00)92282-2

An improved, highly diastereoselective procedure is described for the preparation of substituted 4-hydroxy-4,5-dihydrofurans 4 which are structural elements that occur in azadirachtin and several other biologically active natural products. Key Words: Acetylene-dicarboxylic-acid diesters; α-hydroxy-ketones; substituted 4-hydroxy-4,5-dihydrofurans; LiBr-activated cyclization; natural products

Full text of DOI:10.1016/S0040-4039(00)92282-2

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Product name:4,5-diphenyl-4-hydroxy-4,5-dihydrofuran-2,3-dicarboxylic acid di-tert.butyl ester

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