An Improved Procedure for the Preparation of Substituted 4-Hydroxy-4,5-dihydrofurans

Article abstract of DOI:10.1016/S0040-4039(00)92282-2

An improved, highly diastereoselective procedure is described for the preparation of substituted 4-hydroxy-4,5-dihydrofurans 4 which are structural elements that occur in azadirachtin and several other biologically active natural products. Key Words: Acetylene-dicarboxylic-acid diesters; α-hydroxy-ketones; substituted 4-hydroxy-4,5-dihydrofurans; LiBr-activated cyclization; natural products