Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors

DOI: 10.1016/j.bmcl.2012.03.089

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3488 - 3491 (2012)

Update date:2022-08-04

Topics:

Authors:

Shi, Junxing

Zhou, Longhu

Amblard, Franck

Bobeck, Drew R.

Zhang, Hongwang

Liu, Peng

Bondada, Lavanya

McBrayer, Tamara R.

Tharnish, Phillip M.

Whitaker, Tony

Coats, Steven J.

Schinazi, Raymond F.

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Article abstract of DOI:10.1016/j.bmcl.2012.03.089

NS5A inhibitors are a new class of direct-acting antiviral agents which display very potent anti-HCV activity in vitro and in humans. Rationally designed modifications to the central biphenyl linkage of a known NS5A series led to selection of several comp

Full text of DOI:10.1016/j.bmcl.2012.03.089

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