Induced fit conformational changes of a "reversed amidine" heterocycle: Optimized interactions in a DNA minor groove complex

DOI: 10.1021/ja069003n

Source and publish data:

Journal of the American Chemical Society p. 5688 - 5698 (2007)

Update date:2022-09-26

Topics:

Authors:

Munde, Manoj

Lee, Michael

Neidle, Stephen

Arafa, Reem

Boykin, David W.

Liu, Yang

Bailly, Christian

Wilson, W. David

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Article abstract of DOI:10.1021/ja069003n

To better understand the molecular basis for recognition of the DNA minor groove by heterocyclic cations, a series of "reversed amidine" substituted heterocycles has been prepared. Amidine derivatives for targeting the minor groove have the amidine carbon

Full text of DOI:10.1021/ja069003n

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