Enantioselective addition of (Z)- And (E)-alkenylzinc bromides to aldehydes: Asymmetric synthesis of sec-allylalcohols

Article abstract of DOI:10.1016/S0040-4039(00)93553-6

In situ prepared (Z)- and (E)-1-alkenylzinc bromides 5 were added to various aldehydes 1 in the presence of lithiated (+)-N-methylephedrine or (+)-2-(N,N-dimethylamino)-1,2-diphenylethanol to give sec. allyalcohols 7 in high optical purity with simple rec