Reactivity of in situ Generated Dihalomethyllithium towards Dicarboxylic Acid Diesters and Lactones: Synthetic Applications

DOI: 10.1016/S0040-4020(01)81943-8

Source and publish data:

Tetrahedron p. 7875 - 7886 (1991)

Update date:2022-09-26

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Authors:

Barluenga, Jose

Llavona, Lujan

Yus, Miguel

Concellon, Jose M.

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Article abstract of DOI:10.1016/S0040-4020(01)81943-8

The reaction of dicarboxylic acid diesters 1, with in situ generated dihalomethyllithium (1:1.4 molar ratio) at -78 deg C leads, after hydrolysis, to the corresponding dihalomethylketoesters 3.The same process using an excess of the carbenoid (1:4 molar r

Full text of DOI:10.1016/S0040-4020(01)81943-8

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