Structure-activity study of antihypertensive 1,4-dihydropyridine derivatives having nitrooxyalkyl moieties at the 3 and 5 positions

DOI: 10.1248/cpb.41.1060

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1060 - 1065 (1993)

Update date:2022-08-05

Topics:

Authors:

Kawashima

Ogawa Ogawa

Kato Kato

Nakazato

Tsuchida

Hatayama

Hirono Hirono

Moriguchi

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Article abstract of DOI:10.1248/cpb.41.1060

1,4-Dihydropyridine derivatives having two nitrooxyalkyl moieties as esters at the 3 and 5 positions possess antihypertensive activity. To understand how substituents affect the biological activity, the quantitative structure-activity relationship (QSAR) of 27 compounds was analyzed using the Fuzzy adaptive least-squares (FALS 91) method. The QSAR models suggested that the hydrophobicity and electronic effect at the 4 position of the 1,4- dihydropyridine along with the special structures of the nitrooxyalkylester components are important for antihypertensive activity.

Full text of DOI:10.1248/cpb.41.1060

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