Structure-activity study of antihypertensive 1,4-dihydropyridine derivatives having nitrooxyalkyl moieties at the 3 and 5 positions

DOI: 10.1248/cpb.41.1060

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1060 - 1065 (1993)

Update date:2022-08-05

Topics:

Authors:

Kawashima

Ogawa Ogawa

Kato Kato

Nakazato

Tsuchida

Hatayama

Hirono Hirono

Moriguchi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.41.1060

1,4-Dihydropyridine derivatives having two nitrooxyalkyl moieties as esters at the 3 and 5 positions possess antihypertensive activity. To understand how substituents affect the biological activity, the quantitative structure-activity relationship (QSAR) of 27 compounds was analyzed using the Fuzzy adaptive least-squares (FALS 91) method. The QSAR models suggested that the hydrophobicity and electronic effect at the 4 position of the 1,4- dihydropyridine along with the special structures of the nitrooxyalkylester components are important for antihypertensive activity.

Full text of DOI:10.1248/cpb.41.1060

NII-Electronic Library Service

Products guided by the article

Product name:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-[2-(trifluoromethyl)phenyl]-

Cas No:138279-31-9

R&D Labs maybe for 138279-31-9

Suzhou Kangrun Pharmaceutical, Inc

Contact:86-512-63912376，63913329

Address:Building 2, No. 2358 ,Chang'an Rd, Wujiang Economic Development Zone Pioneering park, china
Suzhou Jingye Medicine & Chemical Co., Ltd

Contact:+86-512-66658588

Address:No. 88, Sanlian Street, Jinfeng Road, Suzhou New District, Jiangsu Province, P. R. China
Borun Chemical Co.,Ltd.

Contact:+86-574- 87178138; 87297407

Address:No. 809, Liudingxingzuo, cangsong road, Ningbo, China
Tianjin Te-An Chemtech Co., Ltd.(expird)

Contact:+86-22-65378638

Address:A5-8, No.80 Haiyun Street, TEDA
Shandong Yaroma Perfumery Co., Ltd.

Contact:+86- 531- 88024598

Address:7-702 Caizhi Central, 59 Gong Ye South Road, Jinan City,250101, P. R. China

Relevant to this article

Convenient synthesis of 1,2,4-benzotrithiins from benzopentathiepin with phosphorus ylide

Doi:10.1016/0040-4039(91)80165-3
(1991)
MONO- AND DI-(2-NITROGUANIDINO)BENZENES AND SOME OF THEIR AMINO AND NITRO DERIVATIVES

Doi:10.1007/BF00961048
(1991)
Very high stereoselectivity in organocatalyzed desymmetrizing aldol reactions of 3-substituted cyclobutanones

Doi:10.1039/c2ob25813g
(2012)
Synthesis, spectral characterization and larvicidal activity of acridin-1(2H)-one analogues

Doi:10.1016/j.saa.2012.04.015
(2012)
[Pd(μ-Br)(P^tBu₃)]₂ as a highly active isomerization catalyst: Synthesis of enol esters from allylic esters

Doi:10.1021/ol301563g
(2012)
Synthesis of the hexasaccharide from Trypanosoma cruzi mucins with the Galp(1?→?2)Galf unit constructed with a superarmed thiogalactopyranosyl donor

Doi:10.1016/j.carres.2019.06.013
(2019)

Article Doi