Structure-activity study of antihypertensive 1,4-dihydropyridine derivatives having nitrooxyalkyl moieties at the 3 and 5 positions

DOI: 10.1248/cpb.41.1060

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1060 - 1065 (1993)

Update date:2022-08-05

Topics:

Authors:

Kawashima

Ogawa Ogawa

Kato Kato

Nakazato

Tsuchida

Hatayama

Hirono Hirono

Moriguchi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.41.1060

1,4-Dihydropyridine derivatives having two nitrooxyalkyl moieties as esters at the 3 and 5 positions possess antihypertensive activity. To understand how substituents affect the biological activity, the quantitative structure-activity relationship (QSAR) of 27 compounds was analyzed using the Fuzzy adaptive least-squares (FALS 91) method. The QSAR models suggested that the hydrophobicity and electronic effect at the 4 position of the 1,4- dihydropyridine along with the special structures of the nitrooxyalkylester components are important for antihypertensive activity.

Full text of DOI:10.1248/cpb.41.1060

NII-Electronic Library Service

Products guided by the article

Product name:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-[2-(trifluoromethyl)phenyl]-

Cas No:138279-31-9

R&D Labs maybe for 138279-31-9

Shandong Ailitong New Material Co.,Ltd

Contact:+86-536-3226266

Address:zhongjia village, putong town , qingzhou city,Shandong Province,China
Xiamen XM-Innovation Chemical Co., Ltd

Contact:+86-592-3216205

Address:Unit Q, 11/F, No.1 Office Building, Wuyuan Bay Business Center, Huli District, Xiamen City, Fujian Province, P.R.C
Changzhou Litong Chemical Co., Ltd.

website:http://www.litonchem.com/

Contact:+86-519-86301238

Address:Laoba Rd, Hutang town Changzhou Jiangsu
Zhongshan Haihong Medicine Co., Ltd.

Contact:86-0760-86925778 （0）18824993998

Address:A7 building,lianyuan road Torch Hi-tech Industrial Development Zone
Chen jie

Contact:027-87677569

Address:Room 2203, yujingmingmen Buidling One, xiongchu Road, wuhan city, hubei province, China

Relevant to this article

Convenient synthesis of 1,2,4-benzotrithiins from benzopentathiepin with phosphorus ylide

Doi:10.1016/0040-4039(91)80165-3
(1991)
MONO- AND DI-(2-NITROGUANIDINO)BENZENES AND SOME OF THEIR AMINO AND NITRO DERIVATIVES

Doi:10.1007/BF00961048
(1991)
Very high stereoselectivity in organocatalyzed desymmetrizing aldol reactions of 3-substituted cyclobutanones

Doi:10.1039/c2ob25813g
(2012)
Synthesis, spectral characterization and larvicidal activity of acridin-1(2H)-one analogues

Doi:10.1016/j.saa.2012.04.015
(2012)
[Pd(μ-Br)(P^tBu₃)]₂ as a highly active isomerization catalyst: Synthesis of enol esters from allylic esters

Doi:10.1021/ol301563g
(2012)
Synthesis of the hexasaccharide from Trypanosoma cruzi mucins with the Galp(1?→?2)Galf unit constructed with a superarmed thiogalactopyranosyl donor

Doi:10.1016/j.carres.2019.06.013
(2019)

Article Doi