Chemical and Pharmaceutical Bulletin p. 1060 - 1065 (1993)
Update date:2022-08-05
Topics:
Kawashima
Ogawa
Kato
Nakazato
Tsuchida
Hatayama
Hirono
Moriguchi
1,4-Dihydropyridine derivatives having two nitrooxyalkyl moieties as esters at the 3 and 5 positions possess antihypertensive activity. To understand how substituents affect the biological activity, the quantitative structure-activity relationship (QSAR) of 27 compounds was analyzed using the Fuzzy adaptive least-squares (FALS 91) method. The QSAR models suggested that the hydrophobicity and electronic effect at the 4 position of the 1,4- dihydropyridine along with the special structures of the nitrooxyalkylester components are important for antihypertensive activity.
View MoreShenZhen InnoSyn Biotech Co.,Ltd
website:http://www.innosyns.com
Contact:+86-755-28351685
Address:Floor 5 & 6, Building A1, HAIKEXING Strategic Innovative Industrial Park, 16 BaoShan Road, PingShan District
Zhenjiang Haitong Chemical Industry Co., Ltd.
Contact:+86 (511) 8448-0369
Address:Baoyan Town, Dantu District, Zhenjiang City, Jiangsu, China
Suzhou Credit International Trading Co., Ltd
Contact:+86-512-65398039
Address:Qingdeng, Hightech. District, Suzhou
Anqing World Chemical Co., Ltd.
Contact:+86-556-5800026
Address:Daguan Economic Development Zone of circular economy industrial park Anqing City Anhui province
SEA BRGIHT INDUSTRY CO.,LIMITED
Contact:0086 755 8622 3990
Address:Rm 17B3,GuangCaiXinTianDi Bldg,GuiMiao Rd,NanShan District,Shenzhen,China
Doi:10.1016/0040-4039(91)80165-3
(1991)Doi:10.1007/BF00961048
(1991)Doi:10.1039/c2ob25813g
(2012)Doi:10.1016/j.saa.2012.04.015
(2012)Doi:10.1021/ol301563g
(2012)Doi:10.1016/j.carres.2019.06.013
(2019)
