Chemical and Pharmaceutical Bulletin p. 1060 - 1065 (1993)
Update date:2022-08-05
Topics:
Kawashima
Ogawa
Kato
Nakazato
Tsuchida
Hatayama
Hirono
Moriguchi
1,4-Dihydropyridine derivatives having two nitrooxyalkyl moieties as esters at the 3 and 5 positions possess antihypertensive activity. To understand how substituents affect the biological activity, the quantitative structure-activity relationship (QSAR) of 27 compounds was analyzed using the Fuzzy adaptive least-squares (FALS 91) method. The QSAR models suggested that the hydrophobicity and electronic effect at the 4 position of the 1,4- dihydropyridine along with the special structures of the nitrooxyalkylester components are important for antihypertensive activity.
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