Carbohydrate Research p. 129 - 135 (1992)
Update date:2022-07-29
Topics:
Rivera-Sagredo
Fernandez-Mayoralas
Jimenez-Barbero
Martin-Lomas
Villanueva
Aragon
4-O-β-D-Galactopyranosyl-D-xylose (2) was prepared from benzyl 2,3-O-isopropylidene-β-D-xylopyranoside by glycosylation with 2,3,4,6-tetra-O-benzoyl-α-D-galactopyranosyl bromide and subsequent deprotection. Compound 2 was hydrolyzed in vitro by intestinal lactase; the V(max) was 25% of that with lactose and the K(m) was 370 mM (cf. 27 mM for lactose). Oral administration of 2 to suckling rats led to urinary excretion of D-xylose which could be estimated colorimetrically. 4-O-β-D-Galactopyranosyl-D-xylose (2) was prepared from benzyl 2,3-O-isopropylidene-β-D-xylopyranoside by glycosylation with 2,3,4,6-tetra-O-benzoyl-α-D-galactopyranosyl bromide and subsequent deprotection. Compound 2 was hydrolyzed in vitro by intestinal lactase; the Vmax was 25% of that with lactose and the Ktu was 370mM (cf. 27mM for lactose). Oral administration of 2 to suckling rats led to urinary excretion of D-xylose which could be estimated colorimetrically.
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(1992)Doi:10.1021/om300448a
(2012)Doi:10.1016/S0020-1693(00)80921-4
(1991)Doi:10.1002/jhet.5570280727
(1991)Doi:10.1021/jo900637f
(2009)Doi:10.1021/jm300818k
(2012)