1,3-Dipolar Cycloaddition Between Ethyl Trifluoroacetoacetate and N-(Benzylidene)methylamine N-Oxide

DOI: 10.1039/P19910002888

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 2888 - 2889 (1991)

Update date:2022-07-30

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Authors:

Begue, Jean-Pierre

Bonnet-Delpon, Daniele

Lequeux, Thierry

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Article abstract of DOI:10.1039/P19910002888

The 1,3-dipolar cycloaddition between ethyl trifluoroacetoacetate and N-(benzylidene)methylamine N-oxide, performed in boiling toluene, leads regio- and stereo-selectively to an isoxazolidine, while the corresponding ethyl acetoacetate is found to be unreactive under the same conditions.On the other hand, α-trifluoromethylstyrene behaves as α-methylstyrene and affords two diastereoisomeric trifluoromethyl-substituted cycloadducts.

Full text of DOI:10.1039/P19910002888

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