Lipase-catalyzed enantioselective synthesis of optically active mephrobarbital, hexobarbital and febarbamate

DOI: 10.1248/cpb.40.2605

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2605 - 2609 (1992)

Update date:2022-09-26

Topics: Lipase Enantioselective synthesis Optically active

Authors:

Murata Murata

Uchida Uchida

Achiwa Achiwa

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Article abstract of DOI:10.1248/cpb.40.2605

Chiral 5,5-disubstituted N-acyloxymethylbarbiturates have been obtained in 40-99% optical yields by lipase-catalyzed hydrolyses of 5,5-disubstituted N,N'-bisacyloxymethylbarbiturates in H₂O-saturated diisopropyl ether. These chiral barbiturates

Full text of DOI:10.1248/cpb.40.2605

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