Chemical and Pharmaceutical Bulletin p. 2605 - 2609 (1992)
Update date:2022-09-26
Topics: Lipase Enantioselective synthesis Optically active Mephrobarbital, hexobarbital, and febarbamate
Murata
Uchida
Achiwa
Chiral 5,5-disubstituted N-acyloxymethylbarbiturates have been obtained in 40-99% optical yields by lipase-catalyzed hydrolyses of 5,5-disubstituted N,N'-bisacyloxymethylbarbiturates in H2O-saturated diisopropyl ether. These chiral barbiturates
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