Asymmetric synthesis of L-diphenylalanine and L-9-fluorenylglycine via room temperature alkylations of a sultam-derived glycine imine

Article abstract of DOI:10.1016/0040-4039(91)80217-T

L-diphenylalanine and L-9-fluorenylglycine were prepared from a sultam-derived glycine imine 3 via room temperature-asymmetric-alkylation/hydrolysis/mild-sultam-clivage. The L-configuration was ascertained using an X-ray analysis of the alkylation product 4b.