Journal of Medicinal Chemistry p. 1191 - 1200 (1992)
Update date:2022-07-30
Topics:
Harper, Richard W.
Herron, David K.
Bollinger, Nancy G.
Sawyer, J. Scott
Baldwin, Ronald F.
et al.
A hypothetical model for receptor binding of leukotriene D4 (LTD4) was deduced from conformational analysis of LTD4 and from the structure-activity relationships (SAR) of known LTD4 receptor antagonists.A new structural series of LTD4 receptor antagonists exemplified by 5-<4-(4-phenylbutoxy)phenyl>-2-<4-(tetrazol-5-yl)butyl>-2H-tetrazole was designed in which a phenyltetrazole moiety was incorporated as a receptor binding equivalent of the triene unit of LTD4.A number of these phenyltetrazoles were prepared and found to possess LTD4 receptor antagonist activity.The structure-activity relationship (SAR) of this series is described.
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