On the reversal of the stereoselectivity in the Evans aldol reaction of α-amino aldehydes

DOI: 10.1016/0040-4039(91)80500-6

Source and publish data:

Tetrahedron Letters p. 7287 - 7290 (1991)

Update date:2022-08-03

Topics:

Authors:

Hayashi Hayashi

Hamada Hamada

Shioiri Shioiri

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Article abstract of DOI:10.1016/0040-4039(91)80500-6

Reversal of the stereoselectivity in the Evans aldol reaction of Boc-(S)-prolinal (3), observed during the total synthesis of dolastatin 10 (1), was proved to be due to the amounts of dibutylboron triflate and triethylamine. (R)-Alaninal derivatives (14)

Full text of DOI:10.1016/0040-4039(91)80500-6

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