Journal of labelled compounds and radiopharmaceuticals p. 597 - 604 (2005)
Update date:2022-08-02
Topics:
Sontakke
Patil
Unny
Sivaprasad
A convenient synthesis of chloramphenicol labelled with carbon-14 in the dichloroacetyl group at the 1 position is described. It was prepared as part of a 4-step sequence from [1-14C] glycine and the product was purified by preparative HPLC. A radiochemical yield of 47% was obtained based on [1- 14C] glycine and the product had a specific activity of 0.47 mCi/mmol. The procedure can be employed for the synthesis of high specific activity [14C] chloramphenicol, labelled at 1, 2 or both the positions of dichloroacetyl group. Copyright
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