Journal of the Chemical Society. Perkin transactions I p. 3329 - 3332 (1991)
Update date:2022-08-04
Topics:
Prasad, J. Siva
Okuniewicz, Frank J.
Delaney, Edward J.
The synthesis of monogadolinium 10-(1-hydroxypropan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyltriacete 12 has been achieved trough a multistep sequence.The key step in the synthesis was the reaction of the previously unknown tribenzyl 1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylate 6 with ethyl 2-(trifluoromethylsulphonyloxy)propionate 4 to give 7.Reduction of 7 with LiBH4/9-OMe-BBN, followed by hydrogenolysis of the protecting groups (Z groups) yielded 2-(1,4,7,10-tetraazacyclododec-1-yl)propanol 10.The monosubstituted macrocycle 10 was alkylated withbromoacetic acid and then complexed with gadolinium oxide to yield the title compound.
View Morezhejiang huangyan wanfeng pharm chem co.ltd
Contact:+86-576- 84160728
Address:No. 5 Dazha Road, Economic,Development Zone(JiangKou), Zhejiang, China
Shandong General Materials Co.,Ltd（Shandong Aoertong Chemical Co., Ltd）
Contact:86-531-88072280
Address:No. 1825 Hualong Road, Licheng District, Jinan, Shandong, China
Nanjing Spring & Autumn Biological Engineering Co., Ltd.
Contact:86-180510-83338
Address:Suite# 210, No. 1 BuildingNanjing Agricultural Biotechnology High-tech Entrepreneurship Center, No. 4 Tongwei Road, Xuanwu District, Nanjing,China
Hunan Haili Chemical Industry Co.,Ltd.
Contact:+86-731-85521860
Address:No.251, 2nd Section, Furong Road, Changsha,Hunan,China
Anhui Qingyun Pharmaceutical and Chemical Co.,Ltd
Contact:+86-551-63633067
Address:Shuangfeng Road Hefei Anhui
Doi:10.1016/j.tetlet.2012.05.148
(2012)Doi:10.1002/hlca.19670500140
(1967)Doi:10.1021/jm00085a018
(1992)Doi:10.1016/j.tetlet.2012.05.142
(2012)Doi:10.1002/jhet.808
(2012)Doi:10.1021/acs.orglett.7b02510
(2017)
