Journal of the Chemical Society. Perkin transactions I p. 3329 - 3332 (1991)
Update date:2022-08-04
Topics:
Prasad, J. Siva
Okuniewicz, Frank J.
Delaney, Edward J.
The synthesis of monogadolinium 10-(1-hydroxypropan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyltriacete 12 has been achieved trough a multistep sequence.The key step in the synthesis was the reaction of the previously unknown tribenzyl 1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylate 6 with ethyl 2-(trifluoromethylsulphonyloxy)propionate 4 to give 7.Reduction of 7 with LiBH4/9-OMe-BBN, followed by hydrogenolysis of the protecting groups (Z groups) yielded 2-(1,4,7,10-tetraazacyclododec-1-yl)propanol 10.The monosubstituted macrocycle 10 was alkylated withbromoacetic acid and then complexed with gadolinium oxide to yield the title compound.
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