Journal of the Chemical Society. Perkin transactions I p. 3245 - 3251 (1991)
Update date:2022-07-29
Topics:
Hunter, Gordon A.
McNab, Hamish
Monahan, Lilian C.
Blake, Alexander J.
Alkylation of 1-substituted 1H-pyrrol-3(2H)-ones 1 in the presence of base generally gives a mixture of O-alkylated 3, C,O-dialkylated 4 and C,C-dialkylated 5 products.The proportion of C-alkylation is increased by the use of a soft alkylating agent (e.g. iodomethane) and a solvent of l ow polarity (e.g.THF), whereas O-alkylation is favoured by hard alkylating agents (e.g. methyl toluene-p-sulphonate), and dipolar aprotic solvents (e.g. dimethylimidazolidinone).These latter conditions give a good preparative route to a wide range of 1-substituted and 1,2-disubstituted 3-alkoxypyrroles 3 (65-90percent yield).The X-ray crystal structure of 1-tert-butyl-3-methoxy-2-phenylpyrrole 22 is reported.
View MoreContact:732.938.2777
Address:5012 Industrial Road Farmingdale, NJ 07727
ChangZhou XiaQing Chemical Co., Ltd.
Contact:+86-519-88721665
Address:3# Hengluo Road, Henglin Town, Changzhou City, Jiangsu Province,China
Zhejiang Golden-Shell Pharmaceutical Co.,Ltd.
Contact:+86-576-87501888 / 87501988
Address:No.89 Zhongxing Road. Li'ao, Yuhuan, Zhejiang, China
Nantong Kaixin Pharma Chemical Co.,Ltd.
Contact:86-513-85250786
Address:2-1103 Huachen Mansion, 111 Gongnong Road,Nantong, Jiangsu, China
website:http://www.hybio.com.cn
Contact:+86 755 26588093
Address:No.9 Linkong West Street, Hengdian Street, Huangpi District, Wuhan City, China.
Doi:10.1016/0040-4039(91)80213-P
(1991)Doi:10.1021/ja01126a069
(1952)Doi:10.1016/j.bmc.2012.05.072
(2012)Doi:10.1021/jf60148a014
(1966)Doi:10.1016/j.bmc.2012.05.075
(2012)Doi:10.1021/ol403673e
(2014)