SYNTHESIS OF A NUMBER OF COMBINED ANALOGUES OF SUBSTANCE P AND LITORIN

Article abstract of DOI:10.1007/BF00629803

With the aim of obtaining new biologically active compounds, we have synthesized nine combined peptides (I)-(IX) consisting of combinations of the C-terminal tripeptide litorin and the hydrophobic central fragments of substance P, and also modified analogues of them.The synthesis of these compounds was achieved by the methods of classical peptide chemistry with the condensation of their N-terminal moieties with the C-terminal tripeptide H-His-Phe-Met-NH2.