Synthesis of γ-Hydroxy Ketones by LiClO4-Catalyzed Addition of Lithium Enolates to 1,2-Epoxides

Article abstract of DOI:10.1016/0040-4039(91)80540-M

A simple, efficient, anti-stereoselective, highly regioselective method is described for the synthesis of γ-hydroxy ketones by the direct opening of 1,2-epoxides with lithium enolates derived from simple ketones in anhydrous THF, in the presence of LiClO4