Synthesis of γ-Hydroxy Ketones by LiClO4-Catalyzed Addition of Lithium Enolates to 1,2-Epoxides

DOI: 10.1016/0040-4039(91)80540-M

Source and publish data:

Tetrahedron Letters p. 7583 - 7586 (1991)

Update date:2022-08-04

Topics:

Authors:

Chini, Marco

Crotti, Paolo

Favero, Lucilla

Pineschi, Mauro

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Article abstract of DOI:10.1016/0040-4039(91)80540-M

A simple, efficient, anti-stereoselective, highly regioselective method is described for the synthesis of γ-hydroxy ketones by the direct opening of 1,2-epoxides with lithium enolates derived from simple ketones in anhydrous THF, in the presence of LiClO4

Full text of DOI:10.1016/0040-4039(91)80540-M

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