Preparation of two methyl deoxyfluoro-beta-D-galactopyranosides, and their interaction with galactan-specific immunoglobulin A J539 (Fab').

DOI: 10.1016/S0008-6215(00)85575-5

Source and publish data:

Carbohydrate research p. 189 - 194 (1981)

Update date:2022-08-04

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Authors:

Ittah Ittah

Glaudemans

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Article abstract of DOI:10.1016/S0008-6215(00)85575-5

Methyl 2-deoxy-2-fluoro-beta-D-glactopyranoside (2) and methyl 4-deoxy-4-fluoro-beta-D-glactopyranoside (7) have been prepared, and the possibility of their binding to (1 leads to 6)-beta-D-galactopyranan-specific immunoglobulin A J539 (Fab') has been investigated. Compound 2 does not show binding, whereas 7 does. It appears that the 2-hydroxyl group of methyl beta-D-galactopyranoside may take part in hydrogen bonding to the protein.

Full text of DOI:10.1016/S0008-6215(00)85575-5

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