Synthesis of metabolites of S-1452, an orally active thromboxane A2 receptor antagonist

DOI: 10.1248/cpb.39.2842

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2842 - 2848 (1991)

Update date:2022-08-04

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Authors:

Watanabe

Matsuura

Shirahase

Ohtani Ohtani

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Article abstract of DOI:10.1248/cpb.39.2842

The synthesis of 16 metabolites of S-1452, an orally active thromboxane A₂ (TXA₂) receptor antagonist, is described. Regioselective hydroxylation at C-5 or C-6 of the bicyclo[2.2.1]heptane skeleton of the optically active intermediat

Full text of DOI:10.1248/cpb.39.2842

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