Palladium-Catalyzed Carbonylative Annulation Reactions Using Aryl Formate as a CO Source: Synthesis of 2-Substituted Indene-1,3(2H)-dione Derivatives

Article abstract of DOI:10.1021/acs.joc.5b01758

An efficient synthesis of 2-substituted indene-1,3(2H)-diones from stable and readily available 1-(2-halophenyl)-1,3-diones by employing phenyl formate as a CO source has been developed. The reaction occurred via palladium-catalyzed intramolecular carbonylative annulation using K₃PO₄ as a base and DMSO as a solvent at 95 °C. In this protocol, the reaction showed a broad substrate scope with good to excellent yields.

Full text of DOI:10.1021/acs.joc.5b01758

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Article
Palladium-Catalyzed Carbonylative Annulation Reactions
using Aryl Formate as a CO Source: Synthesis of
2-Substituted Indene-1,3(2H)-dione Derivatives
Ying Zhang, Jing-Lei Chen, Zhen-Bang Chen, Yong-Ming Zhu, and Shun-Jun Ji
J. Org. Chem., Just Accepted Manuscript • DOI: 10.1021/acs.joc.5b01758 • Publication Date (Web): 09 Oct 2015
Downloaded from http://pubs.acs.org on October 19, 2015
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Palladium-Catalyzed Carbonylative Annulation Reactions using Aryl
Formate as a CO Source: Synthesis of 2-Substituted Indene-1,3(2H)-dione
Derivatives
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Ying Zhang,† Jing-Lei Chen,† Zhen-Bang Chen,† Yong-Ming Zhu,†,* Shun-Jun Ji‡,*
†College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China
E-mail: zhuyongming@suda.edu.cn; Fax: (+86)-512-67166591
‡College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China
E-mail: shunjun@suda.edu.cn; Fax: (+86)-512-65880307
ABSTRACT: An efficient synthesis of 2-substituted indene-1,3(2H)-diones from stable and readily
available 1-(2-halophenyl)-1,3-diones by employing phenyl formate as a CO source has been
developed. The reaction occurred via palladium-catalyzed intramolecular carbonylative annulation
using K3PO4 as a base and DMSO as a solvent at 95 oC. In this protocol, the reaction showed a broad
substrate scope with good to excellent yields.
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INTRODUCTION
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Palladium-catalyzed carbonylative transformations of aryl halides have undergone impressive
developments since the pioneering work of Heck and Schoenberg in 1974.1 In the last four decades,
various chemicals such as aldehydes, esters, heterocyclic compounds, etc. have been achieved under
CO atmosphere.2 In recent years, many researchers intended to introduce versatile CO surrogates in
carbonylation processes to displace the use of high toxic and flammable CO.3 Aryl formate was
reported to generate CO in the presence of base under milder reaction conditions.4 The Manabe5 and
Tsuji6 groups have independently reported the use of aryl formate as a CO surrogate to esterify aryl
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Scheme 1. Synthesis of Various Compounds using Aryl Formate as a “CO-free” Source
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halides. Besides, several groups also reported the utility of aryl formate in the construction of
different compounds including phthalimides,7a lactones,7b alkynones,7c and γ-Lactams7d (route a in
Scheme 1). Our group has been aimed at constructing bio-active substances via potent cabonylative
resources as alternative to harmful CO for a long time.8 As part of our ongoing research, we are
making an effort to investigate other molecules that could be gained by employing aryl formate as a
“CO-free” source.
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Figure 1. Representative Pharmaceuticals or Bio-active Compounds Containing 2-Substituted
Indanone Structures
Indanones exist ubiquitously in natural products, pharmaceuticals, pesticides, and could be used
for the preparation of organic light emitting materials, photochromics as well as dyestuff.9-13 For
instance (Figure 1), AChE inhibitor Donepezil (A) has been approved by FDA and EMEA for the
symptomatic treatment of Alzheimer's disease (AD).14 Indanocine (B) demonstrates significant
binding affinity for microtubules15 while C is an inhibitor of the GlyT1 glycine transporter.16 Among
all of the indanones, 2-substituted indene-1,3(2H)-diones can be used for synthesizing different types
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of important compounds, some of which act as inhibitors of CDK,17 VEGFR-2 inhibitors (D),18
antimicrobial components (E),19 and potent anti-tumor drugs (F).20 Useful as this kind of structural
moieties is, approaches for their preparation remain limited by the lack of diversity in starting
materials.21 The most widely used traditional method to obtain them lies in condensing ethyl
phthalate with different ketones using a solution of sodium ethoxide in alcohol as the condensing
agent, but products are usually isolated in low yields by this method.29 Besides, the substrate scope in
this method is limited to a small range, which is only confined to groups on the R2 side (R2 is group
as shown in route b in Scheme 1). In contrast, the palladium-catalyzed carbonylative cyclyzation
using in situ generated CO from aryl formate to produce 2-substituted indene-1,3(2H)-diones has
been proven to be applicable to various substituents in the R2 part, with good to excellent yields.
Thus we report herein a practical and convenient reaction for preparing this skeleton that employs
aryl formate as an environmentally friendly CO source (route b in Scheme 1).
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RESULTS AND DISCUSSION
Initial studies were focused on the reaction of 1a with aryl formate 2 in the presence of
Pd(OAc)2 and XantPhos with DMSO as a solvent under nitrogen. As shown in Table 1, no products
were observed using Et3N as a base (Table 1, entry 1). DBU also seemed to be ineffective in this
reaction (Table 1, entry 2). Gratifyingly, when a strong base sodium tert-butoxide was added instead,
the desired product 2-benzoyl-1H-indene-1,3(2H)-dione (3a) was isolated in 43% yield (Table 1,
entry 3). To our delight, the yield was raised to 80% when inorganic base K3PO4 was used (Table1,
entry 4). In contrast with K3PO4, K2HPO4 gave decreased yield even with prolonged reaction time
(Table 1, entry 5). Other commercially available catalysts were also tested to further improve the
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Table 1. Optimization for the Synthesis of 2-Substituted Indene-1,3(2H)-dionesa
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Entry
2
catalyst
ligand
base
solvent
yieldb (%)
1
2
2a
2a
2a
2a
2a
2a
2a
2a
2a
2a
2a
2a
2a
2a
2b
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Pd(OAc)2
Pd(OAc)2
XantPhos
XantPhos
XantPhos
XantPhos
XantPhos
XantPhos
XantPhos
dppp
Et3N
DBU
DMSO
DMSO
DMSO
DMSO
DMSO
DMSO
DMSO
DMSO
DMSO
DMSO
DMSO
DMF
0
4
3
Pd(OAc)2
NaOtBu
K3PO4
K2HPO4
K3PO4
K3PO4
K3PO4
K3PO4
K3PO4
K3PO4
K3PO4
K3PO4
K3PO4
K3PO4
43
80
55
22
96
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3
4
Pd(OAc)2
5
Pd(OAc)2
6
PdCl2(PPh3)2
PdCl2(MeCN)2
PdCl2(MeCN)2
PdCl2(MeCN)2
PdCl2(MeCN)2
PdCl2(MeCN)2
PdCl2(MeCN)2
PdCl2(MeCN)2
PdCl2(MeCN)2
PdCl2(MeCN)2
PdCl2(MeCN)2
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dppf
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R-BINAP
PPh3
6
XantPhos
XantPhos
XantPhos
XantPhos
XantPhos
69
0
THF
toluene
DMSO
DMSO
0
0
0 (98)c
aGeneral conditions: the reactions were run on a 0.4 mmol scale in solvent (1.0 mL), 2 (0.8 mmol),
catalyst (0.012 mmol), ligand (0.024 mmol), base (0.8 mmol) under nitrogen in a sealed tube for
24 h. bIsolated yields. c98 % of substrate 1a was isolated.
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yield (Table1, entries 6–7). Employment of PdCl2(MeCN)2 delivered the carbonylative cyclization
product in excellent yield (Table 1, entry 7), which was superior to Pd(OAc)2. Among other mono-
and bidentate ligands examined, none of them were found to compete with XantPhos (Table 1,
entries 8–11). Screening of other solvents including DMF, THF and toluene did not give better
results (Table1, entries 12–14). The results indicated that a polar solvent played an important role in
the carbonylative cyclization process. Furthermore, few corresponding products were observed using
formic acid or one of its derivatives, HCO2Et, as CO source (Table 1, entries 15–16). Aryl formate is,
as a result, a much higher active CO donor than HCO2H and HCO2Et in this system. Thus, the best
conditions for this reaction were aryl formate (2 equiv), PdCl2(MeCN)2 (3 mol %) and XantPhos (6
mol %) as the catalyst system, with K3PO4 (2 equiv) as the base and DMSO as the solvent under
nitrogen atmosphere at 95 oC.
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With the optimized reaction conditions in hand, the substrate scope of this palladium-catalyzed
carbonylative reaction was investigated. As illustrated in Table 2, a wide variety of reactants bearing
either electron-withdrawing or electron-donating substituents on the aryl ring could be transformed
into the corresponding compounds 3 in moderate to excellent yields. Halogens, methyl, methoxyl,
ester and naphthyl groups were well-tolerated in this system, and yielded desired products over 80%
(Table 2, entries 1−8). Other enolizable motif-containing heteroaryl scaffolds, bearing thienyl, furyl
on the R2 side also provided targeted products in 68–83% yields under standard conditions (Table 2,
entries 9–11). Substrates with R2 ranging from simple aliphatic to cyclic groups also underwent
carbonylative annulation smoothly and afforded 2-substituted indene-1,3(2H)-diones in good yields
(Table 2, entries 12–16). Compared to the conventional methods known for synthesizing
2-substituted indene-1,3(2H)-diones,21,29 the enolic activation-carbonylative annulation approach
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presented here is more effective and efficient with a broad scope of substrates.
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Table 2. Substrate Scope on the R2 Side of Palladium-Catalyzed Synthesis of 2-Substituted
Indene-1,3(2H)-dione Derivativesa
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entry
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substrate
product
yieldb (%)
96
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1b
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3c
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1g
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1h
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68
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1i
3i
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1j
3j
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1k
3k
3l
1l
1m
1n
1o
3m
3n
3o
3p
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aGeneral conditions: the reactions were run on a 0.4 mmol scale under nitrogen in a sealed
tube, using 2 (0.8 mmol), PdCl2(MeCN)2 (0.012 mmol), XantPhos (0.024 mmol), K3PO4
(0.8 mmol) in DMSO (1.0 mL) at 95 oC for 24 h. bIsolated yields.
Next, we explored the flexibility of the method for various R1 groups (Table 3). Corresponding
products 3q–3x were successfully obtained from 1q–1x with different R1 substituents. Both
electron-rich and electron-poor groups were effectively cyclized (Table 3, entries 1–6). When R1 was
3-iodonaphthalen-2-yl, the catalyst/ligand loading should be doubled owing to its weak aromaticity
(Table 3, entry 7). Additionally, to learn about the steric effect on the R1 side,
1-(2-iodo-3-methylphenyl)-3-phenylpropane-1,3-dione was subjected to the reaction, and a lower
yield of the product was obtained (Table 3, entry 8). Notably, a ketone-enol isomerization
phenomenon was observed from the NMR spectra of compounds 3a-3x.
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Table 3. Substrate Scope on the R1 Side of Palladium-Catalyzed Synthesis of 2-Substituted
Indene-1,3(2H)-dione Derivativesa
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entry
1
substrate
product
yieldb (%)
80
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1q
1r
3q
3r
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3
87
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1s
3s
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80
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1t
1u
1v
1w
3t
3u
3v
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7c
3w
3x
8c
53
1x
aGeneral conditions: the reactions were run on a 0.4 mmol scale under nitrogen in a sealed
tube, using 2 (0.8 mmol), PdCl2(MeCN)2 (0.012 mmol), XantPhos (0.024 mmol), K3PO4
(0.8 mmol) in DMSO (1.0 mL) at 95 C for 24 h. Isolated yields. cwith PdCl2(MeCN)2
o
b
(0.024 mmol), XantPhos (0.048 mmol).
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We also applied this method with a bromo substrate 1bb’, only 6% of desired product 3b,
however, was isolated, and 91% of flavone (3bb’) was formed under the same reaction conditions
(route a in Scheme 2). It suggested that aryl bromide did not react as actively as aryl iodide in this
system. Besides, when using 1y-1aa as substrstes, neither were 2-substituted indene-1,3(2H)-diones
observed nor any remaining substrates were isolated, even though these starting materials are
supposed to be applicable under these conditions (route b in Scheme 2).
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Scheme 2. Scope of other substrates
Indenopyrazole, a novel system containing two fused five-membered rings, was one of the
attractive frameworks for development of kinase inhibitors22 in medicinal chemistry, such as
inhibitors of CDK,17,23 PDGFR tyrosine kinase,24 and EGFR.25 These substances are usually derived
from the corresponding indanones.17,18,23-25 To explore the synthetic utility of our methodology,
carbonylative annulation of 1-(2-iodophenyl)-3-phenylpropane-1,3-dione (1a) was conducted on
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gram scale under standard conditions (Scheme 3). A yield (94%) comparable to that of the
small-scale experiment was furnished (Table 2, entry 1). Then, 3a was treated with hydrazine hydrate
to give 3-(4-methoxyphenyl)indeno[1,2-c]pyrazol-4(2H)-one with 86% yield. Synthesis of other
indenopyrazoles and their biology activity evaluation are underway in our laboratory.
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Scheme 3. Scale-Up Application of Carbonylative Annulation of 1a
With respect to a plausible reaction mechanism (Scheme 4), we assumed that, initially, substrate
1 is enolic activated into 4, while the aryl formate decomposes into one molecule of CO5 and phenol.
Then, the in situ generated Pd0 species26 undergoes an oxidative addition to give intermediate 5. After
that, intermediate 5 is transformed into acyl palladium species 6 via CO insertion. At last, product 3
is generated through an intramolecular attack of the nucleophile on acyl palladium species 6.
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Scheme 4. Proposed Reaction Mechanism
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CONCLUSION
In conclusion, we have demonstrated a novel and convenient palladium-catalyzed carbonylative
cyclyzation reaction to generate 2-substituted Indene-1,3(2H)-dione derivatives. This methodology
showcases the use of aryl fomate as a CO source to form C-C bond in the presence of an inorganic
base K3PO4, and PdCl2(MeCN)2/XantPhos catalytic system. Such a method is operationally simple
and more effective than previously reported methods. Besides, aryl formate is a greener
carbonylative surrogate than toxic CO gas. Further applications of aryl formate to construct
bio-active materials are under way, and the results will be reported in due course.
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EXPERIMENTAL SECTION
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General Information. Reactants and reagents were purchased from commercial suppliers and used
without further purification. All anhydrous solvents used in the reactions were dried and freshly
distilled. TLC was performed on silica HSGF254 plates. Melting points were determined with a
digital melting-point apparatus. NMR spectra were run in a solution of CDCl3 or DMSO-d6 with
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1
tetramethylsilane (TMS) as internal standard and were reported in parts per million (ppm). H and
13C NMR spectra were obtained at 400/101 MHz (1H/13C). High-resolution mass spectra (HRMS)
analyses were carried out on a chemical ionization (CI) apparatus using time-of-flight (TOF) mass
spectrometry. Infrared (IR) obtained using KBr tablets and wavenumbers in cm−1.
General Experimental Procedure for the Synthesis of substrates 1a−1x. 2-Iodobenzoic acid
(1.01 equiv, 2g, 8.08 mmol) was placed in a 25 mL round-bottomed flask and the excess
o
thionyl-chlorid was added dropwise with stirring. After refluxing at 80 C for about 4 h,
thionyl-chloride was distilled in vacuo to give the corresponding benzoyl chloride and was stored
under toluene (5 mL) until use. LiHMDS (Lithium Hexamethyldisilazide, 1.4 equiv, 11.2 mL, 11.2
mmol) was injected into a toluene solution (10 mL) of acetophenone (1.0 equiv, 0.96 g, 8.0 mmol)
under nitrogen at 0 oC. After stirring at 0 oC for 3 h, benzoyl chloride was added and the mixture was
continued to react for another 5 h. Then the solvent was quenched with 20 mL 1 N HCl and was
extracted with EtOAc (20×3 mL). The organic phase was dried over Na2SO4. After the removal of
the solvent in vacuo, the residue was purified on a silica gel column using petroleum ether/EtOAc as
the eluent to give the substrate 1a (2.33 g, 83%).
Typical Experimental Procedure for the Synthesis of 2-Substituted Indene-1,3(2H)-diones.
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Substrate 1 (0.4 mmol), PdCl2(MeCN)2 (0.03 equiv, 3 mg, 0.012 mmol), Xantphos (0.06 equiv, 14
mg, 0.024 mmol), HCO2Ph (2 equiv, 90 μL, 0.8 mmol) and K3PO4 (2 equiv, 109 mg, 0.8 mmol) were
successively added into a 15 mL sealed tube, using anhydrous DMSO (1.0 mL) as solvent. The
mixture was stirred at 95 oC under nitrogen for 24 h. Upon completion of the reaction as indicated by
TLC, the mixture was diluted with water (5 mL) and extracted with EtOAc (3 mL). The aqueous
phase was separated and acidified to pH 3 with 1 N HCl, and extracted with EtOAc (10×2 mL). The
combined organic layers were dried over Na2SO4. Filtrates were concentrated on a rotary evaporator
and purified on a silica gel column using petroleum ether/EtOAc as the eluent to give the pure target
product.
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Characterization Data for Products (3a−3x). 2-Benzoyl-1H-indene-1,3(2H)-dione (3a).27 Yellow
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solid (96 mg, 96%); mp 109−111 °C. H NMR (400 MHz, CDCl3) δ 14.64 (s, 1H), 8.17–8.11 (m,
2H), 7.84 (t, J = 7.3 Hz, 2H), 7.71 (p, J = 7.4 Hz, 2H), 7.61 (t, J = 7.4 Hz, 1H), 7.51 (t, J = 7.5 Hz,
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2H). C NMR (101 MHz, CDCl3) δ 198.9, 186.8, 179.7, 140.3, 138.0, 135.3, 134.2, 133.7, 131.4,
130.3, 128.1, 122.97, 123.0, 107.6. HRMS (CI): m/z calcd for C16H11O3 [M + H]+, 251.0708; found,
251.0714.
2-(4-Methylbenzoyl)-1H-indene-1,3(2H)-dione (3b).28 Yellow solid (97 mg, 92%); mp 115−117 °C.
1H NMR (400 MHz, CDCl3) δ 15.06 (s, 1H), 8.09 (d, J = 8.0 Hz, 2H), 7.86 (t, J = 6.1 Hz, 2H), 7.76
– 7.69 (m, 2H), 7.33 (d, J = 8.0 Hz, 2H), 2.46 (s, 3H). 13C NMR (101 MHz, CDCl3) δ 199.1, 187.1,
180.0, 145.0, 140.3, 138.0, 135.2, 134.1, 130.5, 129.0, 128.8, 123.0, 122.4, 107.4, 22.0. HRMS (CI):
m/z calcd for C17H13O3 [M + H]+, 265.0865; found, 265.0860.
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2-(4-Methoxybenzoyl)-1H-indene-1,3(2H)-dione (3c).17a Yellow solid (103 mg, 92%); mp
120−122 °C. 1H NMR (400 MHz, CDCl3) δ 15.23 (s, 1H), 8.31 (d, J = 7.6 Hz, 2H), 7.84 (d, J = 6.5
Hz, 2H), 7.71 (p, J = 7.1 Hz, 2H), 7.02 (d, J = 7.6 Hz, 2H), 3.91 (s, 3H). 13C NMR (101 MHz, CDCl3)
δ 199.2, 187.3, 179.5, 164.4, 140.2, 138.0 135.1, 134.0, 133.1, 124.0, 122.9, 122.2, 113.7, 107.0,
55.7. HRMS (CI): m/z calcd for C17H13O4 [M + H]+, 281.0814; found, 281.0816.
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2-(4-Fluorobenzoyl)-1H-indene-1,3(2H)-dione (3d). Yellow solid (91 mg, 85%); mp 176−178 °C. 1H
NMR (400 MHz, CDCl3) δ 8.26 (dd, J = 8.8, 5.4 Hz, 2H), 7.87 (t, J = 7.6 Hz, 2H), 7.74 (m, 2H),
7.20 (t, J = 8.6 Hz, 2H). 13C NMR (101 MHz, CDCl3) δ 199.0, 187.0, 178.5, 166.1 (d, J = 256.2 Hz),
140.3, 138.0, 135.5, 134.3, 133.2 (d, J = 9.4 Hz), 127.7 (d, J = 3.0 Hz), 123.1, 122.5, 115.6 (d, J =
21.9 Hz), 107.6. IR (KBr): ν 2920, 1714, 1692, 1645, 1604, 1572, 1509, 1290, 1240, 1168, 919, 748
cm−1. HRMS (CI): m/z calcd for C16H10FO3 [M + H]+, 269.0614; found, 269.0610.
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2-(2-Naphthoyl)-1H-indene-1,3(2H)-dione (3e).29 Yellow solid (100 mg, 84%); mp 139−141 °C. H
NMR (400 MHz, CDCl3) δ 8.89 (s, 1H), 8.12 (d, J = 8.6 Hz, 1H), 8.03 (d, J = 8.1 Hz, 1H), 7.97–7.84
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(m, 4H), 7.79–7.69 (m, 2H), 7.59 (dt, J = 14.8, 7.1 Hz, 2H). C NMR (101 MHz, CDCl3) δ 199.1,
187.0, 179.8, 140.3, 138.1, 136.0, 135.4, 134.2, 132.8, 132.3, 130.0, 129.0, 128.8, 127.9, 127.8,
126.8, 125.4, 123.0, 122.4, 107.9. HRMS (CI): m/z calcd for C20H13O3 [M + H]+, 301.0865; found,
301.0852.
2-(Benzo[d][1,3]dioxole-5-carbonyl)-1H-indene-1,3(2H)-dione (3f). Yellow solid (94 mg, 80%); mp
143−145 °C. 1H NMR (400 MHz, CDCl3) δ 15.32(s), 8.02 (s, 1H), 7.84 (d, J = 5.1 Hz, 2H), 7.72 (d,
J = 10.2 Hz, 3H), 6.94 (d, J = 8.3 Hz, 1H), 6.08 (s, 2H). 13C NMR (101 MHz, CDCl3) δ 199.2, 187.2,
179.1, 152.7, 147.8, 140.2, 137.9, 135.2, 134.1, 129.7, 127.5, 122.9, 122.3, 110.2, 108.2, 107.1,
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102.1. IR (KBr): ν 3009, 2916, 2865, 1705, 1646, 1595, 1559, 1485, 1262, 1130, 1004, 744 cm−1.
HRMS (CI): m/z calcd for C17H11O5 [M + H]+, 295.0606; found, 295.0605.
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methyl 4-(1,3-dioxo-2,3-dihydro-1H-indene-2-carbonyl)benzoate (3g) Yellow solid (100 mg, 81%);
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mp 160−161 °C. H NMR (400 MHz, CDCl3) δ 14.94 (s, 1H), 8.18 (s, 4H), 7.89 (dd, J = 11.6, 7.1
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Hz, 2H), 7.77 (t, J = 6.1 Hz, 2H), 3.97 (s, 3H). C NMR (101 MHz, CDCl3) δ 198.9, 186.7, 178.2,
166.4, 140.5, 138.2, 135.7, 135.3, 134.5, 134.2, 130.3, 129.3, 123.3, 122.7, 108.4, 52.6. IR (KBr): ν
1717, 1647, 1618, 1591, 1560, 1541,1506, 1426, 1134, 880, 776 cm−1. HRMS (CI): m/z calcd for
C18H13O5 [M + H]+, 309.0763; found, 309.0771.
2-(4-(benzyloxy)benzoyl)-1H-indene-1,3(2H)-dione (3h) Yellow solid (118 mg, 83%); mp 97−99 °C.
1H NMR (400 MHz, CDCl3) δ 15.23 (s, 1H), 8.33–8.29 (m, 2H), 7.87–7.82 (m, 2H), 7.71 (td, J = 6.6,
1.2 Hz, 2H), 7.40 (m, 6H), 7.09 (d, J = 7.1 Hz, 2H), 5.18 (s, 2H). 13C NMR (101 MHz, CDCl3) 13C
NMR (101 MHz, CDCl3) δ 199.2, 187.3, 179.4, 163.6, 140.1, 138.0, 136.2, 135.1, 134.0, 133.1,
128.9, 128.4, 127.7, 124.1, 122.9, 122.3, 114.5, 107.0, 70.4. IR (KBr): ν 3033, 2919, 2850, 1704,
1680, 1638, 1579, 1557, 1505, 1464, 1250, 1121, 740 cm−1. HRMS (CI): m/z calcd for C23H17O5 [M
+ H]+, 357.1127; found, 357.1137.
2-(Thiophene-2-carbonyl)-1H-indene-1,3(2H)-dione (3i).30 Yellow solid (85 mg, 83%); mp
148−150 °C. 1H NMR (400 MHz, CDCl3) δ 15.26 (s, 1H), 9.20 (d, J = 3.4 Hz, 1H), 7.84−7.80 (dd, J
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= 11.4, 6.9 Hz, 3H), 7.73–7.65 (m, 2H), 7.28–7.24 (m, 1H). C NMR (101 MHz, CDCl3) δ 198.9,
187.3, 171.5, 140.2, 137.9, 137.9, 136.2, 135.7, 135.2, 134.0, 128.9, 122.8, 122.3, 105.9. HRMS (CI):
m/z calcd for C14H9O3S [M + H]+, 257.0272; found, 257.0269.
2-(Thiophene-3-carbonyl)-1H-indene-1,3(2H)-dione (3j).31 Yellow solid (70 mg, 68%); mp
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134−136 °C. H NMR (400 MHz, CDCl3) δ 15.32 (s, 1H), 9.51 (s, 1H), 7.96 (d, J = 4.9 Hz, 1H),
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7.80 (t, J = 8.1 Hz, 2H), 7.71–7.63 (m, 2H), 7.36 (d, J = 2.9 Hz, 1H). 13C NMR (101 MHz, CDCl3) δ
199.3, 187.4, 173.1, 140.2, 137.8, 137.7, 135.1, 134.4, 134.0, 128.4, 125.4, 122.8, 122.2, 106.8.
HRMS (CI): m/z calcd for C14H9O3S [M + H]+, 257.0272; found, 257.0274.
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2-(Furan-2-carbonyl)-1H-indene-1,3(2H)-dione (3k).32 Yellow solid (79 mg, 81%); mp 152−154 °C.
1H NMR (400 MHz, CDCl3) δ 15.15 (s, 1H), 8.85 (d, J = 3.7 Hz, 1H), 7.80 (dd, J = 11.7, 4.7 Hz, 3H),
7.73–7.64 (m, 2H), 6.70 (dd, J = 3.7, 1.4 Hz, 1H). 13C NMR (101 MHz, CDCl3) δ 199.0, 186.6,
166.0, 148.6, 146.1, 140.3, 137.9, 135.2, 134.0, 125.4, 122.8, 122.3, 113.7, 105.3. HRMS (CI): m/z
calcd for C14H9O4 [M + H]+, 241.0501; found, 241.0508.
2-Butyryl-1H-indene-1,3(2H)-dione (3l).29 Red-brown oil (65 mg, 75%). 1H NMR (400 MHz, CDCl3)
δ 13.01 (s, 1H), 7.81 (s, 2H), 7.69 (t, J = 6.6 Hz, 2H), 2.94 (t, J = 7.2 Hz, 2H), 1.76 (dd, J = 14.2, 7.0
Hz, 2H), 1.03 (t, J = 7.1 Hz, 3H). 13C NMR (101 MHz, CDCl3) δ 197.3, 188.7, 187.86, 140.8, 138.2,
135.1, 134.2, 122.8, 122.5, 108.6, 34.2, 20.0, 13.9. HRMS (CI): m/z calcd for C13H13O3 [M + H]+,
217.0865; found, 217.0868.
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2-Isobutyryl-1H-indene-1,3(2H)-dione (3m).29 Yellow solid (57 mg, 66%); mp 94−96 °C. H NMR
(400 MHz, CDCl3) δ 13.90 (s, 1H), 7.83 (t, J = 5.8 Hz, 2H), 7.75–7.66 (m, 2H), 3.89 (dt, J = 13.9,
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6.9 Hz, 1H), 1.27 (d, J = 6.9 Hz, 6H). C NMR (101 MHz, CDCl3) δ 197.8, 192.3, 188.5, 140.8,
138.2, 135.1, 134.1, 122.8, 122.5, 107.1, 30.7, 19.0. HRMS (CI): m/z calcd for C13H13O3 [M + H]+,
217.0865; found, 217.0867.
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2-Pivaloyl-1H-indene-1,3(2H)-dione (3n).33 Yellow solid (55 mg, 60%); mp 112−114 °C. H NMR
(400 MHz, CDCl3) δ 16.08 (s, 1H), 7.81–7.77 (m, 2H), 7.72–7.64 (tdd, 2H), 1.43 (s, 9H). 13C NMR
(101 MHz, CDCl3) δ 198.8, 198.0, 186.7, 139.3, 136.9, 134.5, 133.2, 122.2, 121.7, 106.7, 39.3,
25.74. HRMS (CI): m/z calcd for C14H15O3 [M + H]+, 231.1021; found, 231.1028.
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2-(Cyclohexanecarbonyl)-1H-indene-1,3(2H)-dione (3o).29 Red-brown solid (59 mg, 58%); mp
81−83 °C. 1H NMR (400 MHz, CDCl3) δ 7.81 (d, J = 6.2 Hz, 2H), 7.70 (dd, J = 15.0, 7.3 Hz, 2H),
3.59 (t, J = 11.7 Hz, 1H), 1.84 (d, J = 10.4 Hz, 4H), 1.66–1.53 (m, 2H), 1.46–1.37 (m, 2H),
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1.31–1.22 (m, 2H). C NMR (101 MHz, CDCl3) δ 197.9, 191.7, 188.6, 140.8, 138.3, 135.0, 134.1,
122.8, 122.5, 107.2, 40.6, 29.1, 25.8, 25.7. HRMS (CI): m/z calcd for C16H17O3 [M + H]+, 257.1178;
found, 257.1177.
2-(Adamantanecarbonyl)-1H-indene-1,3(2H)-dione (3p). Yellow solid (79 mg, 64%); mp
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131−133 °C. H NMR (400 MHz, CDCl3) δ 16.08 (s, 1H), 7.79 (d, J = 7.2 Hz, 2H), 7.67 (m, 2H),
2.16 (s, 6H), 2.09 (s, 3H), 1.86 (d, J = 11.9 Hz, 3H), 1.77 (d, J = 12.1 Hz, 3H). 13C NMR (101 MHz,
CDCl3) δ 199.6, 198.2, 187.5, 139.9, 137.6, 135.1, 133.8, 122.7, 122.3, 107.4, 42.3, 36.8, 36.5, 28.2.
IR (KBr): ν 2916, 2900, 2849, 1701, 1635, 1593, 1555, 1464, 1291, 1137, 976, 742, 696 cm−1.
HRMS (CI): m/z calcd for C20H21O3 [M + H]+, 309.1491; found, 309.1490.
2-Benzoyl-5-methoxy-1H-indene-1,3(2H)-dione (3q). Yellow solid (90 mg, 80%); mp 125−127 °C.
1H NMR (400 MHz, CDCl3) δ 14.90 (s, 1H), 8.12 (d, J = 7.6 Hz, 2H), 7.79 (t, J = 9.0 Hz, 1H), 7.61
(t, J = 7.2 Hz, 1H), 7.52 (t, J = 7.5 Hz, 2H), 7.31 (d, J = 5.9 Hz, 1H), 7.24–7.16 (m, 1H), 3.94 (d, J =
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3.2 Hz, 3H). C NMR (151 MHz, CDCl3) δ 198.6, 198.0, 186.7, 186.1, 178.5, 178.4, 166.0, 165.0,
143.5, 140.8, 133.5, 133.4, 133.4, 131.7, 131.5, 130.8, 130.4, 130.2, 128.2, 124.8, 124.4, 122.3,
121.2, 108.3, 108.0, 106.6, 105.7, 56.2. IR (KBr): ν 2923, 2815, 1706, 1640, 1607, 1585, 1487, 1289,
1128, 998, 764, 698 cm−1. HRMS (CI): m/z calcd for C17H13O4 [M + H]+, 281.0814; found,
281.0819.
2-Benzoyl-5,6-dimethoxy-1H-indene-1,3(2H)-dione (3r). Yellow solid (108 mg, 87%); mp
188−190 °C. 1H NMR (400 MHz, CDCl3) δ 14.45 (s, 1H), 8.08 (d, J = 7.4 Hz, 2H), 7.59 (t, J = 6.9
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Hz, 1H), 7.50 (t, J = 7.3 Hz, 2H), 7.28 (d, J = 5.0 Hz, 2H), 4.00 (d, J = 6.1 Hz, 6H). 13C NMR (101
MHz, CDCl3) δ 198.1, 186.5, 176.4, 155.4, 154.5, 135.4, 133.1, 132.3, 131.6, 130.2, 128.1, 107.6,
104.4, 103.67, 56.8. IR (KBr): ν 3063, 3015, 2943, 2835, 1701, 1611, 1583, 1567, 1494, 1304, 1287,
1221, 1082, 988, 766, 698 cm−1. HRMS (CI): m/z calcd for C18H15O5 [M + H]+, 311.0919; found,
311.0920.
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2-Benzoyl-5-methyl-1H-indene-1,3(2H)-dione (3s). Yellow solid (95 mg, 90%); mp 109−111 °C. H
NMR (400 MHz, CDCl3) δ 8.13 (t, J = 8.5 Hz, 2H), 7.75 (t, J = 7.0 Hz, 1H), 7.63 (dd, J = 19.2, 8.1
Hz, 2H), 7.52 (t, J = 8.0 Hz, 3H), 7.22 (t, J = 7.6 Hz, 1H), 6.91 (t, J = 7.3 Hz, 1H), 6.84 (d, J = 8.3
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Hz, 1H), 2.50 (s, 3H). C NMR (151 MHz, CDCl3) δ 199.1, 198.8, 187.0, 186.8, 179.2 (d, J = 3.4
Hz), 146.9, 145.5, 140.8, 138.4, 138.1, 136.1, 135.7, 135.0, 133.7, 133.5, 131.5 (d, J = 8.2 Hz), 130.3
(d, J = 7.1 Hz), 128.6, 128.1, 123.4, 122.9, 122.8, 122.4, 108.0 (d, J = 16.9 Hz), 22.3, 22.1. IR (KBr):
ν 3053, 2921, 2852, 1702, 1642, 1601, 1589, 1570, 1489, 1291, 1127, 960, 891, 756, 681 cm−1.
HRMS (CI): m/z calcd for C17H13O3 [M + H]+, 265.0865; found, 265.0864.
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2-Benzoyl-5-fluoro-1H-indene-1,3(2H)-dione (3t). Yellow solid (86 mg, 80%); mp 167−169 °C. H
NMR (400 MHz, CDCl3) δ 14.86 (s, 1H), 8.13 (d, J = 7.4 Hz, 2H), 7.90−7.83 (m, 1H), 7.63 (t, J =
7.4 Hz, 1H), 7.51 (m, 3H), 7.39 (td, J = 9.8, 1.3 Hz, 1H). 13C NMR (101 MHz, CDCl3) δ 197.5,
197.4 (d, J = 2.2 Hz), 185.5, 185.4 (d, J = 2.1 Hz), 180.1, 180.0, 167.5 (d, J = 258.8 Hz), 166.6 (d, J
= 257.2 Hz), 143.4 (d, J = 8.7 Hz), 140.8 (d, J = 9.0 Hz), 136.2 (d, J = 2.6 Hz), 133.9, 131.3, 131.2,
130.5, 130.4, 128.3, 128.2, 125.4 (d, J = 9.3 Hz), 125.0 (d, J = 9.4 Hz), 122.4 (d, J = 23.6 Hz), 121.4
(d, J = 23.9 Hz), 110.4 (d, J = 23.6 Hz), 109.6 (d, J = 23.8 Hz), 108.0, 107.8 (d, J = 17.3 Hz). IR
(KBr): ν 2924, 1705, 1645, 1591, 1568, 1490, 1294, 1121, 962, 759, 683 cm−1. HRMS (CI): m/z
calcd for C16H10FO3 [M + H]+, 269.0614; found, 269.0619.
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2-Benzoyl-5-chloro-1H-indene-1,3(2H)-dione (3u). Yellow solid (89 mg, 78%); mp 179−181 °C. 1H
NMR (400 MHz, CDCl3) δ 14.89 (s, 1H), 8.14 (s, 2H), 7.80 (d, J = 6.5 Hz, 2H), 7.66 (t, J = 14.3, 6.4
Hz, 2H), 7.54 (s, 2H). 13C NMR (101 MHz, CDCl3) δ 197.8, 197.6, 185.6, 185.4, 180.45, 180.4,
142.1, 141.8, 140.8, 139.5, 138.3, 136.1, 135.3, 134.3, 134.0, 131.3, 131.2, 130.4. 130.3, 128.9.
128.7, 124.4, 123.7, 123.4, 122.7, 107.7, 107.6. IR (KBr): ν 2922, 1702, 1647, 1605, 1587, 1563,
1490, 1292, 1140, 962, 760, 682 cm−1. HRMS (CI): m/z calcd for C16H10ClO3 [M + H]+, 285.0318;
found, 285.0320.
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2-Benzoyl-5-chloro-1H-indene-1,3(2H)-dione (3v). Yellow solid (64 mg, 56%); mp 179−180 °C. H
NMR (400 MHz, CDCl3) δ 14.98 (s, 1H), 8.14 (d, J = 7.6 Hz, 2H), 7.81 (m, 2H), 7.80 (t, J = 10.8 Hz,
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1H), 7.72–7.61 (m, 2H), 7.53 (t, J = 7.4 Hz, 2H). C NMR (101 MHz, CDCl3) δ 197.77, 197.57,
185.67, 185.44, 180.53, 180.46, 142.07, 141.80, 140.84, 139.53, 138.35, 136.10, 135.30, 134.28,
134.00, 131.29, 131.22, 130.43, 130.37, 128.29, 128.27, 124.38, 123.75, 123.45, 122.70, 107.75,
107.62. IR (KBr): ν 2922, 1703, 1647, 1586, 1564, 1490, 1292, 1140, 962, 760, 682 cm−1. HRMS
(CI): m/z calcd for C16H10ClO3 [M + H]+, 285.0318; found, 285.0324.
2-Benzoyl-1H-cyclopenta[b]naphthalene-1,3(2H)-dione (3w). Yellow solid (99 mg, 82%); mp
168−170 °C. 1H NMR (400 MHz, CDCl3) δ 8.34 (d, J = 17.9 Hz, 2H), 8.23 (d, J = 7.5 Hz, 2H), 8.12
(d, J = 7.5 Hz, 1H), 8.05 (s, 2H), 7.66 (d, J = 5.7 Hz, 2H), 7.55 (t, J = 7.3 Hz, 2H), 7.48 (t, J = 7.3 Hz,
1H). 13C NMR (101 MHz, CDCl3) δ 198.36, 186.45, 182.16 , 136.72, 135.90, 135.72, 133.96, 133.88,
133.63, 131.81, 130.49, 130.56, 130.54, 130.52, 129.33, 129.02, 128.62, 128.24, 123.87, 123.65,
110.31. IR (KBr): ν 2922, 2851, 1686, 1599, 1585, 1559, 1510, 1290, 1142, 958, 760, 685 cm−1.
HRMS (CI): m/z calcd for C20H13O3 [M + H]+, 301.0865; found, 301.0864.
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2-Benzoyl-4-methyl-1H-indene-1,3(2H)-dione (3x). Yellow solid (56mg, 53%); mp 129−132 °C. H
NMR (400 MHz, CDCl3) δ 15.26 (s, 1H), 8.17−8.08 (m, 2H), 7.75−7.68 (m, 1H), 7.54 (m, 5H), 7.23
(t, J = 7.6 Hz, 1H), 6.83 (d, J = 7.7 Hz, 1H), 2.74 (d, J = 18.8 Hz, 3H). 13C NMR (101 MHz, CDCl3)
δ 200.6, 198.9, 188.6, 187.2, 179.7, 179.6, 138.1, 137.9, 136.6, 134.8, 133.6, 133.6, 133.4, 131.7,
131.6, 130.3, 130.2, 129.7, 128.7, 128.5, 128.2, 120.8, 120.6, 120.2, 115.4, 108.0, 107.8, 18.5, 18.4.
IR (KBr): ν 2924, 2853, 1703, 1599, 1585, 1564, 1488, 1290, 1139, 923, 753, 691 cm−1. HRMS (CI):
m/z calcd for C17H13O3 [M + H]+, 265.0865; found, 265.0867.
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3-Bhenylindeno[1,2-c]pyrazol-4(2H)-one (4a).34 White solid (550 mg, 86%); mp 259−262 °C. H
NMR (400 MHz, DMSO-d6) δ 13.81 (s, 1H), 8.21 (d, J = 7.7 Hz, 2H), 7.61−7.47 (m, 6H), 7.40–7.34
(m, 1H). 13C NMR (101 MHz, DMSO-d6) 184.0, 164.2, 141.9, 140.8, 136.0, 134.0, 130.5, 129.3,
129.2, 126.9, 126.6, 123.9, 119.9, 116.6. HRMS (CI): m/z calcd for C16H11N2O [M + H]+, 247.0871;
found, 247.0886.
ASSOCIATED CONTENT
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Supporting Information Figures giving H and C NMR spectra. This material is available free of
charge via the Internet at http://pubs.acs.org.
AUTHOR INFORMATION
Corresponding Author
*Y.-M. Z.: e-mail, zhuyongming@suda.edu.cn; fax, (+86)-512-67166591. S.-J. J.: e-mail,
shunjun@suda.edu.cn; fax, (+86)-512-65880307.
Notes
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The authors declare no competing financial interest.
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ACKNOWLEDGMENTS
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We gratefully acknowledge financial support by the PAPD (A Project Funded by the Priority
Academic Program Development of Jiangsu Higher Education Institutions) and NSFC (National
Nature Science Foundation of China, No. 21172162).
REFERENCES
(1) (a) Schoenberg, A.; Bartolet, I.; Heck, R. F. J. Org. Chem. 1974, 39, 3318–3326. (b) Schoenberg,
A.; Heck, R. F. J. Org. Chem. 1974, 39, 3327–3331. (c) Schoenberg, A.; Heck, R. F. J. Am.
Chem. Soc. 1974, 96, 7761–7764.
(2) (a) Brennführer, A.; Neumann, H.; Beller, M.; Angew. Chem. 2009, 121, 4176–4196; Angew.
Chem. Int. Ed. 2009, 48, 4114–4133. (b) Wu, X.-F.; Neumann, H.; Beller, M. Chem. Soc. Rev.
2011, 40, 4986–5009. (c) Wu, X.-F.; Neumann, H.; Beller, M. Chem. Rev. 2013, 113, 1–35; (d)
Liu, Q.; Zhang, H.; Lei, A. Angew. Chem. 2011, 123, 10978–10989; Angew. Chem. Int. Ed. 2011,
50, 10788–10799. e) Barnard, C. F. J. Organometallics 2008, 27, 5402–5422.
(3) For a review on carbonylations without using toxic CO gas, see: (a) Morimoto, T.; Kakiuchi, K.
Angew. Chem., Int. Ed. 2004, 43, 5580–5588. For a review on Mo(CO)6 mediated carbonylation,
see: (b) Odell, L. R.; Russo, F.; Larhed, M. Synlett 2012, 23, 685–689. Recent examples for the
uses of CO surrogates: (c) Wu, L.; Liu, Q.; Jackstell, R.; Beller, M. Angew. Chem. Int. Ed. 2014,
53, 6310–6320. (d) Tommasi, S.; Perrone, S.; Rosato, F.; Salomone, A.; Troisi, L. Synthesis
2012, 44, 423. (e) Hermange, P.; Lindhardt, A. T.; Taaning, R. H.; Bjerglund, K.; Lupp, D.;
Skrydstrup, T. J. Am. Chem. Soc. 2011, 133, 6061–6071. (f) Friis, S. D.; Taaning, R. H.;
ACS Paragon Plus Environment

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Page 24 of 28
1
2
3
4
5
6
7
8
9
Lindhardt, A. T.; Skrydstrup, T. J. Am. Chem. Soc. 2011, 133, 18114–18117. (g) Lee, H. W.;
Chan, A. S. C.; Kwong, F. Y. Chem. Commun. 2007, 2633–2635. (h) Morimoto, T.; Yamasaki,
K.; Hirano, A.; Tsutsumi, K.; Kagawa, N.; Kakiuchi, K.; Harada, Y.; Fukumoto, Y.; Chatani, N.;
Nishioka, T. Org. Lett. 2009, 11, 1777–1780. (i) Grushin, V. V.; Alper, H. Organometallics 1993,
12, 3846–3850.
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
(4) (a) Carpentier, J. F.; Castanet, Y.; Brocard, J.; Mortreux, A.; Petit, F. Tetrahedron Lett. 1992, 33,
2001–2004. (b) Carpentier, J. F.; Castanet, Y.; Brocard, J.; Mortreux, A.; Petit, F. Tetrahedron
Lett. 1991, 32, 4705–4708. (c) Schareina, T.; Zapf, A.; Cotte, A.; Gotta, M.; Beller, M. Adv.
Synth. Catal. 2010, 352, 1205–1209. (d) Fleischer, I.; Jennerjahn, R.; Cozzula, D.; Jackstell, R.;
Franke, R.; Beller, M. ChemSusChem 2013, 6, 417–420.
(5) (a) Ueda, T.; Konishi, H.; Manabe, K.; Org. Lett. 2013, 15, 5370–5373. (b) Ueda, T.; Konishi, H.;
Manabe, K. Angew. Chem. Int. Ed. 2013, 52, 8611–8615. (c) Ueda, T.; Konishi, H.; Manabe, K.
Org. Lett. 2012, 14, 5370–5373. (d) Ueda, T.; Konishi, H.; Manabe, K. Tetrahedron Lett. 2012,
53, 5171–5175. (e) Ueda, T.; Konishi, H.; Manabe, K. Org. Lett. 2012, 14, 3100–3103.
(6) Fujihara, T.; Hosoki, T.; Katafuchi, Y.; Iwai, T.; Terao, J.; Tsuji, Y. Chem. Commun. 2012, 48,
8012–8014.
(7) (a) Chavan, S. P.; Bhanage, B. M. Eur. J. Org.Chem. 2015, 2405–2410. (b) Wang, H.; Dong, B.;
Wang, Y. Li, J.; Shi, Y. Org. Lett. 2014, 16, 186–189. (c) Li, H.; Neumann, H.; Beller, M.; Wu,
X.-F. Angew. Chem. Int . Ed. 2014, 53, 3183–3186. (d) Hoshimoto, Y.; Ohata, T.; Sasaoka, Y.;
Ohashi, M.; Ogoshi, S. J. Am. Chem. Soc. 2014, 136, 15877–15880.
(8) (a) Fei, X.-D.; Ge, Z.-Y.; Tang, T.; Zhu, Y.-M.; Ji, S.-J. J. Org. Chem. 2012, 77, 10321–10328. (b)
Tang, T.; Fei, X.-D.; Ge, Z.-Y.; Chen, Z.; Zhu, Y.–M.; Ji, S.-J. J. Org. Chem. 2013, 78,
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6
7
8
9
3170–3175. (c) Zhang, Y.; Jiang, X.; Wang, J.-M.; Chen, J.-L.; Zhu, Y.-M. RSC Adv. 2015, 5,
17060–17063.
(9) (a) Clark, W. M.; Tickner-Eldridge, A. M.; Huang, G. K.; Pridgen, L. N.; Lsen, M. A.; Mills, R. J.;
Lantos, I.; Baine, N. H. J. Am. Chem. Soc. 1998, 120, 4550–4551. (b) Kundu, K.; McCullagh, J.
V.; Morehead, Jr, A. T. J. Am. Chem. Soc. 2005, 127, 16042–16043. (c) Lago, M. A.; Luengo, J.
I.; Peishoff, C. E.; Elliot, J. D. In Annual Reports in Medicinal Chemistry; Bristol, J. A., Ed.;
Academic Press: San Diego, 1996; Vol. 31, p 81.
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
(10) (a) ElSheshtawy, H. S.; Baker, A. M. A. J. Mol. Struc. 2014, 1067, 225–232. (b) Dhareshwar, S.
S.; Stella, V. J. J. Pharm. Scien. 2010, 99, 2711. (c) Gruber, S.; Pregosin, P. S. Advan. Synth.
Catal. 2009, 351, 3235–3242.
(11) (a) Xiao, J.; Deng, Z.-B.; Yao, Y.-S.; Wang, X.-S. Dyes Pigm. 2008, 76, 290–293. (b) Fu, T. L.;
Wang, I. J. Dyes Pigm. 2008, 76, 158–164. (c) Fu, T. L.; Wang, I. J. Dyes Pigm. 2008, 76,
590–595.
(12) (a) Li, X.; Han, J.; Pang, M.; Cheng, K.; He, Z. J. Mol. Struct. 2008, 874, 28–33. (b) Han, J.;
Meng, J–B. J. Photochem. Photobiol. C. 2009, 10, 141–147.
(13) Stiller, B.; Saphiannikova, M.; Morawetz, K.; Ilnytskyi, J.; Neher, D.; Muzikante, I.; Pastors, P.;
Kampars, V. Thin Solid Films. 2008, 516, 8893–8898.
(14) Saxena, H. O.; Faridi, U.; Srivastava, S. Bioorg. Med. Chem. Lett. 2008, 18, 3914–3918.
(15) Shih, H.; Deng, L.; Carrera, C. J.; Adachi, C. J.; Cottam, H. B.; Carson, D. A. Bioorg. Med.
Chem. Lett. 2000, 10, 487–490.
(16) Thomson, C. G.; Duncan, K.; Fletcher, S. R.; Huscroft, I. T.; Pillai, G.; Raubo, P.; Smith, A. J.;
Stead, D. Bioorg. Med. Chem. Lett. 2006, 16, 1388–1391.
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7
8
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(17) (a) Nugiel, D. A.; Vidwans, A.; Etzkorn, A. M.; Rossi, K. A.; Benfield, P. A.; Burton, C. R.; Cox,
S.; Doleniak, D.; Seitz, S. P. J. Med. Chem. 2002, 45, 5224–5232. (b) Yue, E. W.; Higley, C. A.;
DiMeo, S. V.; Carini, D. J;. Nugiel, D. A.; Benware, C.; Benfield, P. A. Burton, C. R.; Cox, S.;
Grafstrom, R. H.; Sharp, D. M.; Sisk, L. M.; Boylan, J. F.; Muckelbauer, J. K.; Smallwood, A.
M.; Chen, H.; Chang, C.-H.; Seitz, S. P.; Trainor, G. L. J. Med. Chem. 2002, 45, 5233–5248.
(18) Usui, T.; Ban, H. S.; Kawada, J.; Hirokawa, T.; Nakamura, H. Bioorg. Med. Chem. Lett. 2008,
18, 285–288.
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
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46
47
48
49
50
51
52
53
54
55
56
57
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60
(19) Mohil, R.; Kumar, D.; Mor, S. J. Heterocyclic Chem. 2014, 51, 203–211.
(20) Insuasty, B.; Orozco, F.; Lizarazo, C.; Quiroga, J. Bioorg. Med. Chem. 2008, 16, 8492–8500.
(21) (a) Schwerin, E. Ber. 1894, 27, 104–114. (b) Rosenfeld, M. J.; Shankar, Ravi, B. K.; Shechter, H.
J. Org. Chem. 1988, 53, 2699–2705. (c) Padwa, A.; Hornbuckle, S. F.; Zhang, Z.-J.; Zhi, L. J.
Org. Chem. 1990, 55, 5297–5299. (d) Shen, Q.-S.; Huang, W.; Wang, J.-L.; Zhou, X.-G. Org.
Lett. 2007, 9, 4491–4494. (e) Partridge, B. M.; Gonzalez J. S.; Lam, H. W. Angew. Chem. Int.
Ed. 2014, 53, 6523–6527.
(22) Saghaie, L.; Shahlaei, M.; Madadkar-Sobhani, A.; Fassihi, A. J. Mol. Graphics Modell. 2010, 29,
518–528.
(23) Nugiel, D. A.; Vidwans, A.; Etzkorn, A.-M.; Rossi, K. A.; Benfield, P. A.; Burton, C. R.; Cox, S.;
Doleniak, D.; Seitz, S. P. J. Med. Chem. 2002, 45, 5224–5232.
(24) Yue, E. W.; Higley, C. A.; DiMeo, S. V.; Carini, D. J.; Nugiel, D. A.; Benware, C.; Benfield, P.
A.; Burton, C. R.; Cox, S.; Grafstrom, R. H.; Sharp, D. M.; Sisk, L. M.; Boylan, J. F.;
Muckelbauer, J. K.; Smallwood, A. M.; Chen, H.; Chang, C.-H.; Seitz, S. P.; Trainor, G. L. J.
Med. Chem. 2002, 45, 5233–5248.
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7
8
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(25) Ho, C. Y.; Ludovici, D. W.; Maharoof, U. S. M.; Mei, J.; Sechler, J. L.; Tuman, R. W.; Strobel, E.
D.; Andraka, L.; Yen, H.-K.; Leo, G.; Li, J.; Almond, H.; Lu, H.; DeVine, A.; Tominovich, R. M.;
Baker, J.; Emanuel, S.; Gruninger, R. H.; Middleton, S. A.; Johnson, D. L.; Galemmo, R. A. J.
Med. Chem. 2005, 48, 8163–8173.
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
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36
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42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
(26) (a) Collman, J. P.; Hegedus, L. S.; Norton, J. R.; Finke, R. G. Principles and Application of
Organotransition Metal Chemistry. University Science Books, Mill Vally. CA, 1987, P. 725. (b)
McCrindle, R.; Ferguson, G.; Arsenault, G. J.; McAlees, A. J.; Stephenson, D. K. J. Chem. Res.
Synop. 1984, 360–361.
(27) Bernasconi, C. F., Ketner, R. J., Ragains, M. L., Chen, X., Rappoport, Z. J. Am. Chem. Soc.
2001, 123, 2155–2164.
(28) Shapiro, S., Geuger, K., Freedman, L. J. Org. Chem. 1960, 25, 1860–1865.
(29) Kilgore, L. B., Ford, J. H., Wolf, W. C. Ind. Eng. Chem. 1942, 34, 494–497.
(30) Quraishi, M. A.; Thakur, V. R. Indian. J. Chem. Techn. 1989, 66, 815–817.
(31) Mosher, W. A.; Soeder, R. W. J. Heterocyclic chem. 1971, 8, 855–859.
(32) Kreicberga, D.; Gudriniece, E.; Zelmene, V. Latvijas PSR Zinatnu Akademijas Vestis, Kimijas
Serija. 1966, 3, 277–282.
(33) Gómez-Canela, C.; Vázquez-Chica, A.; Lacorte, S. Anal. Bioanal. Chem. 2014. 406, 345–358.
(34) Arnold, Lee, D.; Xu, Y.; Barlozzari, T.; Raffertty, P.; Hockley, M.; Turner, A. WO9917770, A1,
1999.
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