Bioreductive fluorescent markers for hypoxic cells: A study of 2- nitroimidazoles with 1-substituents containing fluorescent, bridgehead- nitrogen, bicyclic systems

DOI: 10.1021/jm00088a030

Source and publish data:

Journal of Medicinal Chemistry p. 1920 - 1926 (1992)

Update date:2022-08-05

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Authors:

Hodgkiss

Middleton

Parrick Parrick

Rami Rami

Wardman Wardman

Wilson Wilson

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Article abstract of DOI:10.1021/jm00088a030

The oxygen-sensitive bioreductive binding of 2-nitroimidazoles labeled with fluorescent side chains has been used to stain hypoxic mammalian cells selectively. Several novel compounds were synthesized with a 1-substituent containing a fluorescent, bicycli

Full text of DOI:10.1021/jm00088a030

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